发明授权
EP2808384B1 Modulation of replicative fitness by using less frequently used synonymous codons
有权
通过使用较少使用的同义密码子调节复制适应性
- 专利标题： Modulation of replicative fitness by using less frequently used synonymous codons
- 专利标题（中）： 通过使用较少使用的同义密码子调节复制适应性
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申请号： EP14168068.6申请日： 2005-10-07
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公开(公告)号： EP2808384B1公开(公告)日： 2017-12-06
- 发明人: Kew, Olen M. , Burns, Cara C. , Shaw, Jing , Campagnoli, Raymond , Quay, Jacqueline
- 申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
- 申请人地址： Centers for Disease Control and Prevention Technology Transfer Office 4770 Buford Hwy (K79) Atlanta, Georgia 30341 US
- 专利权人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： Centers for Disease Control and Prevention Technology Transfer Office 4770 Buford Hwy (K79) Atlanta, Georgia 30341 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US617545P 20041008
- 主分类号： A61K39/108
- IPC分类号： A61K39/108 ; C07K14/245 ; C12N7/00 ; A61K39/00 ; C12N15/67
摘要：
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
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