发明公开
EP2811016A1 Embryo quality assessment based on blastomere cleavage and morphology
有权
Embryonenqualitätsbeurteilungauf der Basis von Blastomerspaltung und Morphologie
- 专利标题: Embryo quality assessment based on blastomere cleavage and morphology
- 专利标题(中): Embryonenqualitätsbeurteilungauf der Basis von Blastomerspaltung und Morphologie
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申请号: EP14183079.4申请日: 2012-05-31
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公开(公告)号: EP2811016A1公开(公告)日: 2014-12-10
- 发明人: Ramsing, Niels B , Hilligsoe, Karen Marie , Escrivá, Marcos Meseguer
- 申请人: Unisense FertiliTech A/S
- 申请人地址: Tueager 1 8200 Aarhus N DK
- 专利权人: Unisense FertiliTech A/S
- 当前专利权人: Unisense FertiliTech A/S
- 当前专利权人地址: Tueager 1 8200 Aarhus N DK
- 代理机构: Lewis, Darren John
- 优先权: US201161491483P 20110531
- 主分类号: C12N5/073
- IPC分类号: C12N5/073 ; G06K9/00 ; G01N33/50 ; G06T7/00
摘要:
The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on the timing, and duration of observed cell cleavages and associated cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period, and determining one or more quality criteria for said embryo, wherein said one or more quality criteria is based on the extent of irregularity of the timing of cell divisions when the embryo develops from four to eight blastomeres, and/or wherein said one or more quality criteria is based on determining the time of cleavage to a five blastomere embryo (t5) and wherein t5 is between 48.7 hours and 55.6 hours, and/or wherein said one or more quality criteria is based on the ratio of two time intervals, each of said two time intervals determined as the duration of a time period between two morphological events in the embryo development from fertilization to eight blastomeres, and based on said one or more quality criteria determining the embryo quality.
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