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公开(公告)号：EP3201313B1
公开(公告)日：2020-05-27
申请号：EP15778250.9
申请日：2015-10-02
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公开(公告)号：EP2811016B1
公开(公告)日：2017-10-04
申请号：EP14183079.4
申请日：2012-05-31
CPC分类号： G01N33/5005 , G06K9/0014 , G06T7/0016 , G06T2207/10016 , G06T2207/10056 , G06T2207/20224 , G06T2207/30044
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公开(公告)号：EP3102667A1
公开(公告)日：2016-12-14
申请号：EP15700232.0
申请日：2015-01-13
发明人： RAMSING, Niels , LERCHE HANSEN, Jonas , BØNDERGAARD MADSEN, Kim , KOFOED MEJER, Troels , BERNTSEN, Jørgen
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/50 , C12M25/00 , C12M41/14 , C12M41/36 , C12M41/46 , C12M41/48
摘要： Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a sample platform comprising a plurality of receptacles for holding embryos within the incubation chamber for incubation. The sample platform may comprise a slide carrier on which embryo slides containing the receptacles may be placed incubation. The sample platform is rotatable about a rotation axis relative to the incubation chamber housing so as to allow receptacles to be selectively rotated to a monitoring position that is aligned with a viewing port provided in the incubation chamber housing, for example an opening or window. An imaging device is located outside the incubation chamber and arranged to image embryos within the incubation chamber at the monitoring position through the viewing port.
摘要翻译： 描述了用于监测培养箱中胚胎的装置和方法。 该装置包括由孵育室壳体和样品平台限定的孵育室，样品平台包括多个容纳器，用于将胚胎保持在孵育室内用于孵育。 样品平台可以包括载玻片载体，载玻片载体可以在其上放置容纳接收器的胚胎载玻片。 样品平台可相对于孵育室壳体围绕旋转轴线旋转，以便允许容器选择性地旋转到与设置在孵育室壳体（例如开口或窗口）中的观察口对准的监测位置。 成像装置位于孵育室外部并且被布置成通过观察口将监测位置处的孵育室内的胚胎成像。
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公开(公告)号：EP3102663A1
公开(公告)日：2016-12-14
申请号：EP15700656.0
申请日：2015-01-13
发明人： RAMSING, Niels , BØNDERGAARD MADSEN, Kim , LERCHE HANSEN, Jonas , KOFOED MEJER, Troels , BERNTSEN, Jørgen
摘要： Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a slide carrier comprising a plurality of compartment walls that define compartments for holding embryo slides within the incubation chamber for incubation. The slide carrier is moveable, for example by rotation, relative to the incubation chamber housing to allow a selected compartment to be moved to a loading position defined at least in part by a loading port wall associated with the incubation chamber housing. The loading port wall is arranged to cooperate with the wall of a compartment in the loading position to restrict the extent to which the environment of the compartment in the loading position is in fluid communication with the environments of other compartments in the incubation chamber.
摘要翻译： 描述了用于监测培养箱中胚胎的装置和方法。 该装置包括由孵育室壳体和包含多个隔室壁的载玻片载体限定的孵育室，该多个隔室壁限定用于保持孵育室内的胚胎载玻片用于孵育的隔室。 载玻片可相对于培育室壳体移动，例如通过旋转，以允许选定的室移动到至少部分由与培育室壳体相关的装载口壁限定的装载位置。 装载口壁布置成与装载位置中的隔室的壁配合以限制装载位置中的隔室的环境与培养室中的其他隔室的环境流体连通的程度。
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5.发明公开EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE DIVISION AND MOVEMENT 无效胚胎质量评估基于BLASTOMERENTEILUNG和运动
公开(公告)号：EP2035548A2
公开(公告)日：2009-03-18
申请号：EP07722668.6
申请日：2007-06-15
CPC分类号： C12Q1/02 , A61B17/435 , C12M21/06 , C12M41/46 , C12M41/48 , C12N5/0604 , G01N33/689 , G01N2800/385
摘要： The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
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公开(公告)号：EP3117367B1
公开(公告)日：2018-10-31
申请号：EP15703792.0
申请日：2015-02-12
发明人： PAARUP KYLLING, Anton , BERNTSEN, Jørgen , RAMSING, Niels , PORSGAARD, Søren , QVISTGAARD KAJHØJ, Tine , BERGHOLD KUHLMANN, Reidun
CPC分类号： G06T7/0016 , C12M21/06 , C12M41/46 , G06F3/00 , G06K9/4671 , G06K9/6215 , G06K9/66 , G06T7/246 , G06T11/60 , G06T2207/10016 , G06T2207/30044
摘要： Apparatus and methods for helping a user establish values (e.g. timings) for a plurality of parameters of interest (e.g. cell divisions) relating to the development of an embryo from a series of images of the embryo are described. For each parameter of interest an image is selected for display to a user seeking to establish a value for the parameter of interest. For example, the selected image may be an image predicted to be an image reflecting the value for the parameter of interest. For example, the selected image may be based on a calculated timing for a particular developmental event. The timing may be calculated from a numerical analysis of the images or maybe predetermined. If the user is unable to determine a value for the parameter of interest from the selected image, the user may scroll through neighbouring images until the user can determine a value for the parameter of interest. A value for the proud of interest may then be established in response to user input, for example a user providing an indication that a timing associated with a currently displayed image from the series of images should be taken to be the value of the parameter of interest. The different parameters of interest may be established in an iterative manner in which an initial image for display to a user is selected for each parameter of interest based on the parameter of interest.
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公开(公告)号：EP2906680A1
公开(公告)日：2015-08-19
申请号：EP13776801.6
申请日：2013-10-14
摘要： The invention relates to an incubator having a chamber for cultivating embryos and a gas control system for maintaining a constant atmosphere in the incubating chamber. In a first aspect the invention relates to an incubator for incubating embryos, comprising an incubating chamber adapted to contain the embryos, and a gas unitary module in fluid communication with the incubating chamber comprising at least two proportional valves, a CO
2 gas sensor and an O
2 gas sensor, wherein the gas unitary module is adapted to receive a gas supply of N
2 at one of said proportional valves and CO
2 at another of said proportional valves, and control the proportional valves based on feedback from the gas sensors such that supply of N
2 and CO
2 to the incubation chamber is regulated to sustain a predefined level of O
2 and/or CO
2 in said incubating chamber.-
公开(公告)号：EP2890781A1
公开(公告)日：2015-07-08
申请号：EP13756438.1
申请日：2013-08-29
发明人： RAMSING, Niels B. , LÆGDSMAND, Mette , GUNDERSEN, Jens K. , PORSGAARD, Søren , AGERHOLM, Inge Errebo
摘要： A computer implemented method for automatically detecting variations and/or abnormalities in the developmental conditions of in vitro incubating embryos, the method comprising the steps of: a) obtaining a first dataset comprising morphokinetic parameters relating to the development of a first group of embryos, b) obtaining a second dataset comprising morphokinetic parameters relating to the development of a second group of embryos, c) modifying the first and second datasets by extracting morphokinetic parameter outliers from the first dataset and or the second datasets, d) calculating the difference between specific morphokinetic parameters from the modified first dataset and the corresponding morphokinetic parameters from the modified second dataset, and monitoring said morphokinetic difference thereby detecting variations in the developmental conditions of the first and second group of embryos.
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公开(公告)号：EP2864475A1
公开(公告)日：2015-04-29
申请号：EP13732887.8
申请日：2013-06-25
CPC分类号： G06F19/3437 , C12M21/06 , C12M41/46 , C12M41/48 , C12N5/0604 , G16H50/50
摘要： Methods for determining a development potential for an embryo, for example an in vitro incubating human embryo, and apparatus for implementing such methods are described. In some examples a method comprises obtaining values for a plurality of morphokinetic characteristics relating to the development of an embryo during an observation period, for example characteristics relating to the temporal or morphological development of the embryo. A value for a continuous variable is determined by combining differences between the obtained values for these characteristics and corresponding reference values in a predefined manner. The reference values may, for example, be determined from values for the plurality of characteristics obtained for at least one reference embryo of known development potential. A development potential for the embryo is then established based on the determined value for the continuous variable.
摘要翻译： 描述了确定胚胎发育潜力的方法，例如体外孵育人类胚胎，以及用于实施这些方法的装置。 在一些示例中，一种方法包括获得观察期期间与胚胎发育有关的多个形态动力学特征的值，例如与胚胎的时间或形态发育相关的特征。 连续变量的值通过以预定义的方式组合这些特征的获得值与相应参考值之间的差值来确定。 例如，可以从针对已知发展潜力的至少一个参考胚胎获得的多个特征的值确定参考值。 然后基于连续变量的确定值建立胚胎的发育潜力。
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10.发明公开EMBRYO QUALITY ASSESSMENT BASED ON BLASTOCYST DEVELOPMENT 有权EMBRYO-QUALITÄTSBEURTEILUNGBASIEREND AUF DER BLASTOZYSTENENTWICKLUNG
公开(公告)号：EP2855664A1
公开(公告)日：2015-04-08
申请号：EP13729621.6
申请日：2013-05-31
发明人： RAMSING, Niels B , KRISTENSEN, Morten , LÆGDSMAND, Mette , KUHLMAN, Reidun Berghold , AGERHOLM, Inge Errebo , ISAKSEN, Mai Faurschou , GUNDERSEN, Jens K
CPC分类号： G01N33/5091 , C12N5/0604 , G06K9/00147 , G06K9/6282
摘要： The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on observed cell kinetics and cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period, said time period comprising the transformation of the embryo from initial compaction or morula to blastocyst and determining one or more blastocyst quality criteria for said embryo, and based on said one or more blastocyst quality criteria determining the embryo quality.
摘要翻译： 本发明涉及一种基于观察到的细胞动力学和细胞形态来选择体外受精胚胎的方法和系统。 本发明的一个实施方案涉及一种用于确定胚胎质量的方法，包括在一段时间内监测胚胎，所述时间段包括将胚胎从初始压实或桑ula转化为胚泡并确定所述胚胎的一个或多个胚泡质量标准， 并且基于所述一种或多种确定胚胎质量的胚泡质量标准。
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