- 专利标题： RECOMBINANT POXVIRAL VECTORS EXPRESSING BOTH RABIES AND OX40 PROTEINS, AND VACCINES MADE THEREFROM
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申请号： EP13707085.0申请日： 2013-02-14
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公开(公告)号： EP2814506B1公开(公告)日： 2018-11-28
- 发明人: MEBATSION, Teshome , MINKE, Jules, Maarten , DAVID, Frederic
- 申请人： Merial, Inc.
- 申请人地址： 3239 Satellite Boulevard Bldg. 500 Duluth, GA 30096 US
- 专利权人： Merial, Inc.
- 当前专利权人： Merial, Inc.
- 当前专利权人地址： 3239 Satellite Boulevard Bldg. 500 Duluth, GA 30096 US
- 代理机构： D Young & Co LLP
- 优先权： US201261598610P 20120214
- 国际公布： WO2013123242 20130822
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/008 ; A61K39/39
摘要：
The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
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