公开(公告)号：EP3929210A1

公开(公告)日：2021-12-29

申请号：EP20760142.8

申请日：2020-02-14

申请人： Fundação Oswaldo Cruz

发明人： NETO, Osvaldo, Pompílio, de Melo ,  REZENDE, Antonio, Mauro ,  TAVARES, Diego, de Hollanda, Cavalcanti ,  DOS SANTOS, Wagner, José, Tenório ,  NETO, Artur, Leonel, de Castro ,  MAGALHÃES, Franklin, Barbalho ,  DO NASCIMENTO, Marília, Barbosa

IPC分类号： C07K14/44 ,  C12N15/62 ,  C12N15/63 ,  A61K39/008 ,  C12N1/00 ,  G01N33/569

摘要： The present invention relates to chimeric proteins, their uses and production method comprising native protein fractions from Leishmania infantum for the Visceral Leishmaniasis diagnosis. The invention also relates to nucleic acid, expression cassette, expression vector, host cell, visceral leishmaniasis diagnostic kit, visceral leishmaniasis diagnostic kit, visceral leishmaniasis diagnostic method, and vaccine composition.

公开(公告)号：EP3801608A1

公开(公告)日：2021-04-14

申请号：EP19730700.2

申请日：2019-05-29

申请人： Institut de Recherche pour le Développement ,  INSTITUT PASTEUR DE TUNIS

发明人： BRAS GONÇALVES, Rachel ,  LEMESRE, Jean-Loup ,  GARNAOUI, Amel ,  PETITDIDIER-LESIN, Elodie

IPC分类号： A61K39/008

公开(公告)号：EP3506932A1

公开(公告)日：2019-07-10

申请号：EP17784999.9

申请日：2017-09-02

申请人： Intrexon Actobiotics NV

发明人： ROTTIERS, Pieter ,  STEIDLER, Lothar

IPC分类号： A61K39/008 ,  A61K35/744 ,  C12N15/74

公开(公告)号：EP2890392B1

公开(公告)日：2019-04-17

申请号：EP13760212.4

申请日：2013-08-30

申请人： Merial, Inc.

发明人： FISCHER, Laurent, Bernard ,  CARBOULEC, Nicolas Pierre, Yves ,  LUX, Fabien

IPC分类号： A61K39/008 ,  C07K1/113 ,  C12N15/62

公开(公告)号：EP3251680A1

公开(公告)日：2017-12-06

申请号：EP17163093.2

申请日：2009-05-22

申请人： Infectious Disease Research Institute

发明人： REED, Steven G. ,  CARTER, Darrick

IPC分类号： A61K31/7028 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61P37/00

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

摘要翻译： 基于在基本上均质形式提供的合成的吡喃葡萄糖基脂佐剂（GLA）中发现有用的免疫佐剂性质，公开了用于诱导或增强免疫应答的组合物和方法，包括疫苗和药物组合物。 化学定义，合成GLA提供了批次之间一致的疫苗组分，没有损害天然产物佐剂的污染物或活性的波动。 还提供了包含GLA和一种或多种抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体例如药物载体的疫苗和药物组合物。

公开(公告)号：EP3188756A2

公开(公告)日：2017-07-12

申请号：EP15808270.1

申请日：2015-09-01

申请人： Cadila Healthcare Limited

发明人： GUPTA, Gaurav ,  FICHERA, Epifanio ,  GLUECK, Reinhard

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P33/02 ,  A61K39/008 ,  A61K39/145

CPC分类号： A61K39/008 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55588 ,  C12N7/00 ,  C12N2760/16034 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention is directed to a preparation of an adjuvant system to achieve required level of humoral and cellular immune response against antigen of interest. The current invention provides an adjuvant system comprising an immunostimulating reconstituted influenza virosomes (IRIVs) and immunopotentiators. The current invention illustrates that an antigen is adsorbed or incorporated into IRIVs and further formulated with lipophilic adjuvant such as MPL or glucopyranosyl lipid adjuvant (synthetic analogue of MPL).

摘要翻译： 本发明涉及佐剂系统的制备，以获得针对感兴趣抗原的所需水平的体液和细胞免疫应答。 本发明提供了包含免疫刺激重构流感病毒体（IRIV）和免疫增强剂的佐剂系统。 本发明说明抗原被吸附或掺入IRIV中，并进一步与亲脂性佐剂例如MPL或吡喃葡萄糖基脂佐剂（MPL的合成类似物）一起配制。

公开(公告)号：EP3019193A4

公开(公告)日：2017-03-15

申请号：EP14822269

申请日：2014-07-10

申请人： THE U S A AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES

发明人： CHEN WAN JUN ,  KASAGI SHIMPEI ,  ZHANG PIN

IPC分类号： A61K39/395 ,  A61K35/15 ,  A61K39/00 ,  A61K39/008 ,  A61K45/06 ,  A61P37/00 ,  C07K16/28

CPC分类号： A61K39/3955 ,  A61K35/15 ,  A61K39/0007 ,  A61K39/0008 ,  A61K39/008 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/55566 ,  A61K2039/577 ,  A61K2300/00 ,  C07K16/2812 ,  C07K16/2815 ,  C07K2317/73 ,  C07K2317/75

摘要： The invention provides methods of tolerizing or treating a subject suffering from an autoimmune or autoinflammatory disease or disorder to an antigen associated with the autoimmune disease or disorder. The invention also features kits for carrying out the methods of the invention.

摘要翻译： 本发明提供了耐受或治疗由在自身免疫或自身炎性疾病或病症在与自身免疫性疾病或病症相关的抗原的受试者到的方法。 因此，本发明的特征在于用于实施发明的方法的试剂盒。

公开(公告)号：EP3074418A2

公开(公告)日：2016-10-05

申请号：EP14830587.3

申请日：2014-11-28

申请人： Institut de la Recherche pour le Développement (IRD) ,  VIRBAC

发明人： LEMESRE, Jean-Loup ,  PAPIEROK, Gérard-Marie ,  BRAS GONCALVES, Rachel Elise ,  PETITDIDIER-LESIN, Elodie

IPC分类号： C07K14/44 ,  A61K39/008

CPC分类号： A61K39/008 ,  C07K14/44 ,  Y02A50/41

摘要： The invention relates to the use, as a vaccine molecule in a mammal, of a PSA, such as a Leishmania PSA, or a part of said PSA having immunogenic properties. Said PSA, hereinafter referred to as "ES PSAr", is in a soluble, native, recombinant form. The invention also relates to a vaccine composition for preventing and/or treating Leishmaniases containing an ES PSAr protein.

公开(公告)号：EP2890392A1

公开(公告)日：2015-07-08

申请号：EP13760212.4

申请日：2013-08-30

申请人： Merial, Inc.

发明人： FISCHER, Laurent, Bernard ,  CARBOULEC, Nicolas Pierre, Yves ,  LUX, Fabien

IPC分类号： A61K39/008 ,  C07K1/113 ,  C12N15/62

CPC分类号： C07K14/245 ,  A23L3/0155 ,  A61K39/008 ,  A61K39/0225 ,  A61K39/0241 ,  A61K39/099 ,  A61K2039/552 ,  A61L2/0011 ,  C07K14/44 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/40 ,  C12N5/0031 ,  C12N9/1007 ,  C12N9/50 ,  C12N9/52 ,  C12P21/02 ,  C12Y201/01041 ,  C12Y304/22

摘要： The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.

摘要翻译： 本发明涉及一种高压设备用于灭活微生物和病毒，同时保留它们的免疫原性和用于从来自原核生物或真核生物生产包涵体制备和生产可溶性，分解，重折叠或活性的免疫原性或治疗性蛋白。 本发明包括一种使用灭活的病原体的疫苗组合物用于灭活病原生物体高压方法和方法。 该hyperbarically灭活微生物更安全，比化学灭活微生物的免疫原性更强。 类似地，溶解的蛋白质具有优异的性能相比更重聚集蛋白，包括降低的非特异性免疫反应。

公开(公告)号：EP1279679B1

公开(公告)日：2015-07-08

申请号：EP01971447.6

申请日：2001-04-11

申请人： Laboratorios Leti S.L. Sociedad Unipersonal

发明人： SOTO ALVAREZ, Manuel ,  ALONSO BEDATE, Carlos ,  REQUENA ROLANIA, José Maria

IPC分类号： C07K14/44 ,  G01N33/68 ,  A61K39/008

CPC分类号： C07K14/44 ,  A61K39/00 ,  Y02A50/41

摘要： A composition and method for stimulating an immune response against an antigen in immunised individuals or in cell groups. The composition comprises a protein called Lip2a Leishmania formed by a sequence of amino acids coded for by a sequence of DNA that comprises the nucleotides: 1-1 of nos. 778 to 1231 of SEQ. ID NO ! 1-2 or formed by a sequence of nucleotides able to hybridise with the sequence described in 1-1 under moderately strict hybridisation conditions and which would therefore code for a protein similar to Lip2a. The method comprises incubating said cells with said Lip2a protein in the presence or not of an antigen specific to a disease or infection.