发明公开
EP2817322A2 NEW HOMO- AND HETERODIMERIC SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
有权
HOMO和表格异MIME SMAC化合物作为细胞凋亡诱导剂
- 专利标题： NEW HOMO- AND HETERODIMERIC SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
- 专利标题（中）： HOMO和表格异MIME SMAC化合物作为细胞凋亡诱导剂
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申请号： EP12865538.8申请日： 2012-02-20
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公开(公告)号： EP2817322A2公开(公告)日： 2014-12-31
- 发明人: SENECI, Pierfausto , BELVISI, Laura , COSSU, Federica , DELIA, Domenico , DRAGO, Carmelo , LECIS, Daniele , MAIORANA, Stefano , MANZONI, Leonardo, Pierpaolo , MASTRANGELO, Eloise , MILANI DE MAYO DE MARI, Mario , PEREGO, Paola Maria Chiara , VASILE, Francesca
- 申请人： Universita' degli Studi di Milano , Fondazione IRCCS Istituto Nazionale dei Tumori , CISI Scrl , Fondazione Cariplo
- 申请人地址： Via Festa del Perdono, 7 20122 Milano IT
- 专利权人： Universita' degli Studi di Milano,Fondazione IRCCS Istituto Nazionale dei Tumori,CISI Scrl,Fondazione Cariplo
- 当前专利权人： Universita' degli Studi di Milano,Fondazione IRCCS Istituto Nazionale dei Tumori,CISI Scrl,Fondazione Cariplo
- 当前专利权人地址： Via Festa del Perdono, 7 20122 Milano IT
- 代理机构： Schnappauf, Georg
- 国际公布： WO2013124701 20130829
- 主分类号： C07K5/083
- IPC分类号： C07K5/083 ; C07D487/04 ; A61P35/00 ; A61K31/5517
摘要：
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
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