发明公开
EP2818870A1 COMBINED ANTICANCER DRUG SENSITIVITY-DETERMINING MARKER
审中-公开
KOMBINIERTER MARKER ZUR BESTIMMUNG DER EMPFINDLICHKEITFÜREIN ANTIKREBSMITTEL
- 专利标题： COMBINED ANTICANCER DRUG SENSITIVITY-DETERMINING MARKER
- 专利标题（中）： KOMBINIERTER MARKER ZUR BESTIMMUNG DER EMPFINDLICHKEITFÜREIN ANTIKREBSMITTEL
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申请号： EP13752246.2申请日： 2013-02-22
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公开(公告)号： EP2818870A1公开(公告)日： 2014-12-31
- 发明人: TANIGAWARA, Yusuke , NISHIMUTA, Akito , TSUZAKI, Junya , TAKAHASHI, Hiroyuki
- 申请人： Keio University , Kabushiki Kaisha Yakult Honsha
- 申请人地址： 15-45 Mita 2-chome Minato-ku Tokyo 108-8345 JP
- 专利权人： Keio University,Kabushiki Kaisha Yakult Honsha
- 当前专利权人： Keio University,Kabushiki Kaisha Yakult Honsha
- 当前专利权人地址： 15-45 Mita 2-chome Minato-ku Tokyo 108-8345 JP
- 代理机构： Blodig, Wolfgang
- 优先权： JP2012037448 20120223
- 国际公布： WO2013125675 20130829
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; A61K31/282 ; A61K31/513 ; A61K45/00 ; A61P35/00 ; A61P43/00 ; G01N33/15 ; G01N33/50
摘要：
To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker.
The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD + , and a substance involved in the metabolism of any of these substances.
The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD + , and a substance involved in the metabolism of any of these substances.
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