公开(公告)号：EP4428242A1

公开(公告)日：2024-09-11

申请号：EP22889974.6

申请日：2022-11-02

申请人： Kabushiki Kaisha Yakult Honsha

发明人： ASAHARA, Takashi ,  SUGIMOTO, Takuya

IPC分类号： C12Q1/02 ,  C12Q1/6851 ,  C12Q1/686 ,  G01N33/50

CPC分类号： C12Q1/02 ,  G01N33/50 ,  C12Q1/6851 ,  C12Q1/686

摘要： A method for determining a risk of an adverse event during multimodal treatment is provided. A method for determining a risk of an adverse event during multimodal treatment includes measuring Anaerostipes hadrus in a sample collected from a subject.

公开(公告)号：EP3858344A1

公开(公告)日：2021-08-04

申请号：EP19867502.7

申请日：2019-09-26

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： SUGIMOTO, Shinji ,  TANIGAWARA, Yusuke ,  MATSUO, Mitsuhisa ,  TAKAHASHI, Hiroyuki

IPC分类号： A61K31/282 ,  A61K31/513 ,  A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  A61P43/00 ,  G01N33/50 ,  G01N33/68

摘要： Provided is a marker for determining sensitivity to an anti-cancer agent early after the start of treatment with the anti-cancer agent. The present invention provides a marker for determining sensitivity to an anti-cancer agent early after the start of treatment with the anti-cancer agent, the anti-cancer agent comprising oxaliplatin or a salt thereof, fluorouracil or a salt thereof, and levofolinate or a salt thereof, the marker comprising one or more molecules selected from the group consisting of 2AMAD, 2ABA, 2CYPR, 50PRO, 6AHXA, ADEN, ASP, BETNC, CARB, CSSG, DOPM, GGLCY, GSSG, HYPT, METSF, N6MDA, NOMTR, PHEP, PRO and RIB5P.

公开(公告)号：EP3812009A1

公开(公告)日：2021-04-28

申请号：EP20214606.4

申请日：2013-02-22

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： TANIGAWARA, Yusuke ,  NISHIMUTA, Akito ,  TSUZAKI, Junya ,  TAKAHASHI, Hiroyuki

IPC分类号： A61P35/00 ,  A61P43/00 ,  A61K45/06 ,  A61K31/513 ,  A61K31/555 ,  G01N33/574

摘要： To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker. The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from cysteine-glutathione, 2-aminoadipic acid and guanosine.

公开(公告)号：EP3626829A1

公开(公告)日：2020-03-25

申请号：EP18802093.7

申请日：2018-05-17

申请人： Kabushiki Kaisha Yakult Honsha ,  National University Corporation Nagoya University

发明人： TSUJI, Hirokazu ,  ASAHARA, Takashi ,  NOMOTO, Koji ,  HIRAYAMA, Masaaki ,  OHNO, Kinji

IPC分类号： C12Q1/06 ,  C12N1/20 ,  G01N33/68 ,  G01N33/92 ,  C12Q1/6851

摘要： The present invention relates to a method for simply diagnosing the progress of disease condition of a Parkinson's disease patient. Provided are a method for determining Parkinson's disease using the number of one or more intestinal bacteria selected from the group consisting of Bifidobacterium, Bacteroides fragilis group, Lactobacillus brevis, and Lactobacillus plantarum subgroup and/or the total number of intestinal bacteria as a marker, and a method for determining Parkinson's disease using the blood LPS level and/or the blood LBP level of a Parkinson's disease patient as an indicator.

公开(公告)号：EP3605103A1

公开(公告)日：2020-02-05

申请号：EP18777198.5

申请日：2018-03-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： SUGIMOTO, Shinji ,  TANIGAWARA, Yusuke ,  MATSUO, Mitsuhisa ,  TAKAHASHI, Hiroyuki

IPC分类号： G01N33/68 ,  A61K31/282 ,  A61K31/513 ,  A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  G01N33/50

摘要： Provided is a novel marker for determining sensitivity to an anti-cancer agent. The marker for determining sensitivity to an anti-cancer agent, the anti-cancer agent including oxaliplatin or a salt thereof, fluorouracil or a salt thereof, and levofolinate or a salt thereof, the marker comprising one or more substances selected from the group consisting of 2DG6P, 2MSE, CSSG, DOPM, GSSG, I4A, P2CB, 1-methyl-2-pyrrolidone, ASP, benzamide, glucaric acid, GL6P, Gly-Gly, HYPT and HYPX.

公开(公告)号：EP3530728A1

公开(公告)日：2019-08-28

申请号：EP17861471.5

申请日：2017-10-20

申请人： National University Corporation Gunma University ,  Kabushiki Kaisha Yakult Honsha

发明人： NISHIYAMA, Masahiko ,  ROKUDAI, Susumu ,  YOSHIYAMA, Shinji ,  TAKAHASHI, Hiroyuki

IPC分类号： C12N5/00 ,  C12N5/0793 ,  C12N5/0797 ,  C12N5/10

摘要： Provided is a method for efficiently manufacturing high-purity peripheral nerve cells from undifferentiated cells. The method for manufacturing peripheral nerve cells from undifferentiated cells having an ability to differentiate into peripheral nerve cells includes the following steps (a) and (b): (a) culturing undifferentiated cells having an ability to differentiate into peripheral nerve cells to induce differentiation into neural progenitor cells without detaching a grown colony from a culture vessel; and (b) detaching the neural progenitor cells produced in the step (a) from the culture vessel, then seeding the cells at a seeding density of 2×10 5 to 6×10 5 cells/cm 2 to a culture vessel, and culturing the cells for 14 to 42 days.

公开(公告)号：EP3438656A3

公开(公告)日：2019-05-01

申请号：EP18190252.9

申请日：2010-10-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： TANIGAWARA, Yusuke ,  SUZUKI, Tetsuya ,  NISHIMUTA, Akito ,  SUGIMOTO, Shinji ,  IGARASHI, Yoshiaki

IPC分类号： G01N27/62 ,  A61K31/4745 ,  A61K45/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68

摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.
The marker for determining sensitivity to an anti-cancer agent is formed of one or more substances selected from aspartic acid, asparagine, glycerol 3-phosphate, dihydrobiopterin, lactic acid, 2-methylbutyroylcarnitine, glutathione, a substance or a fragment thereof detected as an anion at m/z of 149.05 to 149.06, a substance or a fragment thereof detected as an anion at m/z of 152.99 to 153.00, a substance or a fragment thereof detected as a cation at m/z of 724.34 to 724.35, the peaks being determined by means of a mass spectrometer, and a substance involved in a metabolic pathway of any of these substances.

公开(公告)号：EP3320900A2

公开(公告)日：2018-05-16

申请号：EP17203691.5

申请日：2012-02-24

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： TANIGAWARA, Yusuke ,  NISHIMUTA, Akito ,  OTANI, Yuki ,  MATSUO, Mitsuhisa

IPC分类号： A61K31/282 ,  A61K33/24 ,  G01N33/574 ,  G01N33/50 ,  A61K31/513

CPC分类号： G01N33/5091 ,  A61K31/132 ,  A61K31/198 ,  A61K31/282 ,  A61K31/513 ,  A61K31/515 ,  A61K31/555 ,  A61K31/7008 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/574 ,  G01N2500/00 ,  G01N2800/52 ,  G01N2800/60 ,  G01N2800/7066 ,  A61K2300/00

摘要： The invention provides a marker for determining sensitivity of a subject having cancer to an anti-cancer agent in a biological sample derived from the subject, said marker being one or more selected from cysteine-glutathione and guanosine, and said anti-cancer agent being selected from oxaliplatin, fluorouracil, and a salt thereof. The invention also provides a method for determining sensitivity of a subject having cancer to an anti-cancer agent selected from oxaliplatin, fluorouracil, and a salt thereof, comprising measuring the level of a substances selected from cysteine-glutathione and guanosine in a specimen derived from the subject.

摘要翻译： 本发明提供了用于确定来自受试者的生物样品中具有癌症的受试者对抗癌剂的敏感性的标记，所述标记是选自半胱氨酸 - 谷胱甘肽和鸟苷中的一种或多种，​​并且选择所述抗癌剂 来自奥沙利铂，氟尿嘧啶及其盐。 本发明还提供了一种用于确定患有癌症的受试者对选自奥沙利铂，氟尿嘧啶及其盐的抗癌剂的敏感性的方法，所述方法包括测量源自以下的样品中选自半胱氨酸 - 谷胱甘肽和鸟苷的物质的水平： 主题。

公开(公告)号：EP1752150B1

公开(公告)日：2016-08-31

申请号：EP05745848.1

申请日：2005-05-31

申请人： Kabushiki Kaisha Yakult Honsha

发明人： YOSHINO, Keisuke ,  NOZAWA, Shigenori ,  ISOZAKI, Masashi ,  SAWADA, Seigo ,  KATO, Ikuo ,  MATSUZAKI, Takeshi

IPC分类号： A61K31/4745 ,  A61K9/127 ,  A61K47/04 ,  A61K47/18 ,  A61K47/24 ,  A61K47/30 ,  A61P35/00

CPC分类号： A61K9/1271 ,  A61K31/4745

公开(公告)号：EP3054295A1

公开(公告)日：2016-08-10

申请号：EP14849036.0

申请日：2014-09-26

申请人： Kabushiki Kaisha Yakult Honsha

发明人： MIZUKOSHI Harumi ,  KIMURA Kazumasa

IPC分类号： G01N30/88 ,  G01N30/06 ,  G01N30/26 ,  G01N30/86

CPC分类号： G01N30/06 ,  G01N30/88 ,  G01N33/02 ,  G01N33/143 ,  G01N2030/067 ,  G01N2030/8836 ,  Y10T436/143333

摘要： Provide a method for accurately quantifying 4'-GL and galacto-oligosaccharide by separating 4'-GL with ease and at low cost from a sample containing galacto-oligosaccharide and dextrin.
A method for detecting and quantifying galacto-oligosaccharide, which is a method for detecting and quantifying galacto-oligosaccharide in a sample containing galacto-oligosaccharide and dextrin, characterized in that the sample is caused to react with a derivatizing reagent to derivatize the dextrin and galacto-oligosaccharide in the sample, after which the galacto-oligosaccharide component in the sample is separated by high-performance liquid chromatography using a C30 reverse-phase chromatography column.

摘要翻译： 提供一种通过从含有低聚半乳寡糖和糊精的样品中以低成本分离4'-GL来准确定量4'-GL和半乳寡糖的方法。 一种用于检测和定量半乳寡糖的方法，其是含有半乳寡糖和糊精的样品中的低聚半乳糖的检测和定量的方法，其特征在于使样品与衍生试剂反应以衍生糊精和半乳糖 - 寡糖，之后通过使用C30反相色谱柱的高效液相色谱分离样品中的低聚半乳糖成分。