发明公开
- 专利标题： NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
- 专利标题（中）： 芳香族杂环CONNECTION含氮
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申请号： EP13754501申请日： 2013-02-26
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公开(公告)号： EP2821402A4公开(公告)日： 2015-08-19
- 发明人: KAMEDA MINORU , KURIWAKI IKUMI , IIKUBO KAZUHIKO , HISAMICHI HIROYUKI , KAWAMOTO YUICHIRO , MORITOMO HIROYUKI , SUZUKI TOMOYUKI , FUTAMI TAKASHI , SUZUKI ATSUSHI , TSUNOYAMA KAZUHISA , ASAUMI MAKOTO , TOMIYAMA HIROSHI , NODA ATSUSHI , IWAI YOSHINORI , TOKUZAKI KAZUO , OKADA HARUKI , MIYASAKA KOZO
- 申请人： ASTELLAS PHARMA INC , KOTOBUKI PHARMACEUTICAL CO LTD
- 专利权人： ASTELLAS PHARMA INC,KOTOBUKI PHARMACEUTICAL CO LTD
- 当前专利权人： ASTELLAS PHARMA INC,KOTOBUKI PHARMACEUTICAL CO LTD
- 优先权： JP2012042065 2012-02-28
- 主分类号： C07D239/42
- IPC分类号： C07D239/42 ; A61K31/4545 ; A61K31/506 ; A61P35/00 ; A61P43/00 ; C07D239/47 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D405/14 ; C07D413/12 ; C07D471/10 ; C07D487/20
摘要：
Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.
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