-
公开(公告)号：EP2821402A4
公开(公告)日：2015-08-19
申请号：EP13754501
申请日：2013-02-26
发明人： KAMEDA MINORU , KURIWAKI IKUMI , IIKUBO KAZUHIKO , HISAMICHI HIROYUKI , KAWAMOTO YUICHIRO , MORITOMO HIROYUKI , SUZUKI TOMOYUKI , FUTAMI TAKASHI , SUZUKI ATSUSHI , TSUNOYAMA KAZUHISA , ASAUMI MAKOTO , TOMIYAMA HIROSHI , NODA ATSUSHI , IWAI YOSHINORI , TOKUZAKI KAZUO , OKADA HARUKI , MIYASAKA KOZO
IPC分类号： C07D239/42 , A61K31/4545 , A61K31/506 , A61P35/00 , A61P43/00 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D471/10 , C07D487/20
CPC分类号： C07D239/47 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D451/02 , C07D451/04 , C07D453/02 , C07D471/08 , C07D471/10 , C07D487/10 , C07D491/107
摘要： Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.
-
公开(公告)号：EP2824181A4
公开(公告)日：2015-07-15
申请号：EP13757006
申请日：2013-03-07
申请人： ASTELLAS PHARMA INC
发明人： SUZUKI ATSUSHI , ASAUMI MAKOTO , TSUNOYAMA KAZUHISA , NISHIMURA KOUICHI , MORINAKA AKIFUMI , YAMAUCHI TOMOHIRO , YOSHINO MASAYASU , YOSHIZAKI HIROAKI
CPC分类号： A61K31/506 , A61K31/4439 , A61K31/496 , C07K14/47 , C07K14/71 , C07K2319/00 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/57407 , G01N33/57423 , G01N33/74 , G01N2333/50
摘要： [Problem] The present invention aims to elucidate a polynucleotide as a novel responsible gene for cancer and aims to thus provide a method for detecting the polynucleotide and a polypeptide encoded by the polynucleotide and a detection kit, a probe set, and a primer set for the detection. The present invention also aims to provide a pharmaceutical composition for treating cancer. [Means for Solution] The method detects a fusion gene composed of a portion of an FGFR3 gene and a portion of a TACC3 gene or a fusion protein encoded by the fusion gene. The primer set, the probe set, or the detection kit comprises a sense primer and a probe set designed from the portion encoding FGFR3 and an antisense primer and a probe set designed from the portion encoding TACC3. Since an inhibitor of the polypeptide exhibits antitumor effect, a pharmaceutical composition for treating cancer which is positive for either the fusion gene or the polypeptide is provided.
-
搜索结果
2 条记录 (耗时 0.01 秒)
