发明公开
EP2827147A1 Vibrio cholerae lipoprotein 15 (Lp15) variants as anti-interference additive in TpN17-based immunoassays for detection of anti-Treponema antibodies
有权
霍乱弧菌脂蛋白15（LP15）变体作为抗干扰在添加剂的tpn17基于免疫测定用于检测抗密螺旋体抗体
- 专利标题： Vibrio cholerae lipoprotein 15 (Lp15) variants as anti-interference additive in TpN17-based immunoassays for detection of anti-Treponema antibodies
- 专利标题（中）： 霍乱弧菌脂蛋白15（LP15）变体作为抗干扰在添加剂的tpn17基于免疫测定用于检测抗密螺旋体抗体
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申请号： EP14177199.8申请日： 2014-07-16
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公开(公告)号： EP2827147A1公开(公告)日： 2015-01-21
- 发明人: Faatz, Elke , Schaarschmidt, Peter , Schmitt, Urban , Scholz, Christian
- 申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
- 申请人地址： Sandhofer Straße 116 68305 Mannheim DE
- 专利权人： Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人： Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人地址： Sandhofer Straße 116 68305 Mannheim DE
- 代理机构： Poredda, Andreas
- 优先权： EP13003633 20130718
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/571
摘要：
The invention relates to a method for detecting antibodies against the TpN17 antigen of Treponema pallidum in an isolated sample wherein a peptide sequence of Vibrio cholerae lipoprotein 15 ( Vc Lp15) or a partial sequence thereof is used as a reagent for reduction of interference , i.e. for minimizing false positive results. In addition the invention relates to fusion polypeptides comprising a Vc Lp15 peptide sequence and a chaperone, to their use as an additive in an immunoassay for said reduction of interferences and for minimizing false positive results and to a reagent kit for detecting antibodies against Treponema pallidum antigens in an isolated sample comprising a TpN17 antigen and said Vc Lp15-chaperone fusion polypeptide.
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