发明公开
EP2835133A1 Role of N-2-hydroxy-ethyl-piperazine-N'-2-ethane sulfonic acid (HEPES) in reversal of demyelinization injury
审中-公开
Rolle von N-2-Hydroxyethyl-piperazin-N'-2-ethansulfonsäure（HEPES）bei der Umkehrung vonDemyelinisationsläsion
- 专利标题： Role of N-2-hydroxy-ethyl-piperazine-N'-2-ethane sulfonic acid (HEPES) in reversal of demyelinization injury
- 专利标题（中）： Rolle von N-2-Hydroxyethyl-piperazin-N'-2-ethansulfonsäure（HEPES）bei der Umkehrung vonDemyelinisationsläsion
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申请号： EP14191925.8申请日： 2010-09-17
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公开(公告)号： EP2835133A1公开(公告)日： 2015-02-11
- 发明人: Danhof, Ivan E.
- 申请人： North Texas Medical Associates
- 申请人地址： 222 Sw 2nd Street Suite 201 Grand Prairie, TX 75051-1770 US
- 专利权人： North Texas Medical Associates
- 当前专利权人： North Texas Medical Associates
- 当前专利权人地址： 222 Sw 2nd Street Suite 201 Grand Prairie, TX 75051-1770 US
- 代理机构： Sonn & Partner Patentanwälte
- 优先权： US243464P 20090917
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; A61K31/496 ; A61K31/4965 ; A61P25/28
摘要：
Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.
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