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1.发明公开Role of N-2-hydroxy-ethyl-piperazine-N'-2-ethane sulfonic acid (HEPES) in reversal of demyelinization injury 审中-公开Rolle von N-2-Hydroxyethyl-piperazin-N'-2-ethansulfonsäure（HEPES）bei der Umkehrung vonDemyelinisationsläsion
公开(公告)号：EP2835133A1
公开(公告)日：2015-02-11
申请号：EP14191925.8
申请日：2010-09-17
发明人： Danhof, Ivan E.
IPC分类号： A61K31/495 , A61K31/496 , A61K31/4965 , A61P25/28
CPC分类号： A61K31/495
摘要： Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.
摘要翻译： 本文公开了HEPES和衍生物在治疗与癌症相关的疼痛和副作用（包括化疗后认知缺损）中的组合物和治疗用途。 HEPES还用于治疗神经变性和神经系统疾病，脱髓鞘损伤，以及与苯二氮卓类，抗抑郁药和其他神经系统药物相关的副作用和戒断症状。
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公开(公告)号：EP2661274A1
公开(公告)日：2013-11-13
申请号：EP11854913.8
申请日：2011-01-06
发明人： DANHOF, Ivan, E.
IPC分类号： A61K36/886 , A61K31/715 , A61K9/14 , A61P35/00 , A61P37/02 , A61P37/04 , C08B37/04
CPC分类号： A61K31/715 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/736 , A61K45/06 , C08L5/00
摘要： The present invention describes a method for preparing a polymannan extract from freeze- dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis C.
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3.发明公开ANTI-VIRAL PROPERTIES OF ALOE VERA AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) TREATMENT 审中-公开芦荟和治疗后天IMUNSCHWÄCHESYNDROM的抗病毒特性（AIDS）
公开(公告)号：EP2595643A1
公开(公告)日：2013-05-29
申请号：EP11810330.8
申请日：2011-07-20
发明人： DANHOF, Ivan, E.
IPC分类号： A61K36/886 , A61K31/715 , A61P31/18
CPC分类号： A61K31/715 , A23L33/30 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K31/135 , A61K31/736 , A61K36/886 , A61K2300/00 , A23V2200/324 , A23V2250/06 , A23V2250/1882 , A23V2250/2102
摘要： A pharmaceutical composition comprising a combination of formulations derived from Aloe vera for the treatment of Acquired Immune Deficiency Syndrome (AIDS) or HIV infection is described herein. The composition comprises: (i) an injectable sterile polymannan extract, (ii) Raidox (aloe anthraquinones and their diacetyl derivatives), and (iii) a freeze dried aloe vera powder, aloe vera juice, aloe gel or a combination. In addition one or more nutritional supplements comprising fatty acids, proteins, minerals and metals, vitamins, salts, amino acids, and other pharmaceutically acceptable excipients may also be include to counteract the chronic diarrhea, digestive upsets, and weight loss seen in some patients before and during the treatment course. A method for treating the AIDS or HIV infection using the composition of the present invention is also disclosed.
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4.发明公开ROLE OF N-2 HYDROXY-ETHYL-PIPERAZINE-N'-2-ETHANE SULFONIC ACID (HEPES) IN PAIN CONTROL AND REVERSAL OF DEMYELINIZATION INJURY 审中-公开作者N-2-羟乙基哌嗪-N'-2-乙硫酸（HEPES）疼痛缓解作用和DEMYELINISIERUNGSLÄSIONEN的处置
公开(公告)号：EP2477626A2
公开(公告)日：2012-07-25
申请号：EP10817952.4
申请日：2010-09-17
发明人： DANHOF, Ivan, E.
IPC分类号： A61K31/495 , A61K31/496 , A61K31/4965 , A61P25/24 , A61P25/30
CPC分类号： A61K31/495
摘要： Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.
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