发明公开
EP2836229A1 LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS
有权
与寡肽髓鞘碱性蛋白，药物用于治疗多发性硬化症的组成和方法LIPOSOME
- 专利标题： LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS
- 专利标题（中）： 与寡肽髓鞘碱性蛋白，药物用于治疗多发性硬化症的组成和方法LIPOSOME
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申请号： EP13715237.7申请日： 2013-04-11
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公开(公告)号： EP2836229A1公开(公告)日： 2015-02-18
- 发明人: GABIVOV, Alexander , BELOGUROV, Alexey , PONOMARENKO, Natalia , SMIRNOV, Ivan , BACON, Andrew , GREGORIADIS, Gregory
- 申请人： Lipoxen Technologies Limited
- 申请人地址： Fifth Floor 15 Whitehall London SW1 2DD GB
- 专利权人： Lipoxen Technologies Limited
- 当前专利权人： Lipoxen Technologies Limited
- 当前专利权人地址： Fifth Floor 15 Whitehall London SW1 2DD GB
- 代理机构： Schlich, George
- 优先权： US201213444788 20120411
- 国际公布： WO2013153179 20131017
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K9/127 ; C07K14/47
摘要：
A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (R1)a-P1-R2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS:1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
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