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1.发明公开LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS 有权与寡肽髓鞘碱性蛋白，药物用于治疗多发性硬化症的组成和方法LIPOSOME
公开(公告)号：EP2836229A1
公开(公告)日：2015-02-18
申请号：EP13715237.7
申请日：2013-04-11
发明人： GABIVOV, Alexander , BELOGUROV, Alexey , PONOMARENKO, Natalia , SMIRNOV, Ivan , BACON, Andrew , GREGORIADIS, Gregory
CPC分类号： A61K9/127 , A61K39/0008 , C07K14/4713
摘要： A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (R1)a-P1-R2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS:1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
摘要翻译： 一种用于多发性硬化的治疗组合物包括连接于第一向量的第一髓鞘碱性蛋白（MBP）肽，所述第一肽MBP由氨基酸序列组成：（R1）一个P1-R2）b worin P1是氨基 具有至少85％的同一性，在选自由SEQ ID NOS的选择的氨基酸序列氨基酸序列：1-3; 每个R1和R2是氨基酸1至10个氨基酸的unabhängig由...组成的氨基酸序列; 以及每个a和bunabhängig0或1。 髓鞘碱性蛋白的免疫肽成分被封装在甘露脂质体。 在一个具体的实施方案中，组合物包含mylein碱性蛋白（MBP）肽MBP（46-62），MBP（124-139），和MBP（147-170）。
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公开(公告)号：EP2836229B1
公开(公告)日：2018-12-05
申请号：EP13715237.7
申请日：2013-04-11
发明人： GABIVOV, Alexander , BELOGUROV, Alexey , PONOMARENKO, Natalia , SMIRNOV, Ivan , BACON, Andrew , GREGORIADIS, Gregory
CPC分类号： A61K9/127 , A61K39/0008 , C07K14/4713
摘要： A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (R1)a-P1-R2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS:1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
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