发明公开
EP2836515A1 LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
审中-公开
组合物弱酸物种和方法进行生产及其用途
- 专利标题： LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
- 专利标题（中）： 组合物弱酸物种和方法进行生产及其用途
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申请号： EP13786072.2申请日： 2013-10-18
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公开(公告)号： EP2836515A1公开(公告)日： 2015-02-18
- 发明人: RAMASUBRAMANYAN, Natarajan , YANG, Lihua , HERIGSTAD, Matthew, Omon , YANG, Hong , SUBRAMANIAN, Kartik , ZENG, Xiaobei , DONG, Diane, D. , LIM, Wen, Chung , GIFFORD, Kathreen, A. , KAYMAKCALAN, Zehra , CHUMSAE, Christopher
- 申请人： AbbVie Inc.
- 申请人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 代理机构： Lock, Graham James
- 优先权： PCT/US2013/031485 20130314; PCT/US2013/031681 20130314
- 国际公布： WO2014158231 20141002
- 主分类号： C07K16/24
- IPC分类号： C07K16/24
摘要：
The instant invention relates to low acidic species (AR) compositions comprising a protein,
e.g ., an antibody, or antigen-binding portion thereof, and methods,
e.g ., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder,
e.g. , a disorder in which TNFα is detrimental, are also provided.
e.g ., an antibody, or antigen-binding portion thereof, and methods,
e.g ., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder,
e.g. , a disorder in which TNFα is detrimental, are also provided.
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