专利检索 ap:("AbbVie Inc.") AND inv:"KAYMAKCALAN, Zehra" 第 1 页

1.

发明公开
LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME 审中-公开
标题翻译：组合物弱酸物种和方法进行生产及其用途

公开(公告)号：EP2836515A1

公开(公告)日：2015-02-18

申请号：EP13786072.2

申请日：2013-10-18

申请人： AbbVie Inc.

发明人： RAMASUBRAMANYAN, Natarajan , YANG, Lihua , HERIGSTAD, Matthew, Omon , YANG, Hong , SUBRAMANIAN, Kartik , ZENG, Xiaobei , DONG, Diane, D. , LIM, Wen, Chung , GIFFORD, Kathreen, A. , KAYMAKCALAN, Zehra , CHUMSAE, Christopher

IPC分类号： C07K16/24

CPC分类号： C07K16/241 , C07K1/165 , C07K1/18 , C07K1/22

摘要： The instant invention relates to low acidic species (AR) compositions comprising a protein,
e.g ., an antibody, or antigen-binding portion thereof, and methods,
e.g ., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder,
e.g. , a disorder in which TNFα is detrimental, are also provided.

摘要翻译： 在本发明涉及到低的酸性物质（AR）的组合物，其包含蛋白质，E. G.，抗体或其抗原结合部分，和方法，E. G.，细胞培养物和/或蛋白纯化方法的用于制造寻求低AR的组合物。使用搜索组合物治疗疾病的方法，E. G.，其中TNFα的一个障碍是有害的，所提供的。

2.

发明公开
MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME 审中-公开
标题翻译：方法调制C-末端赖氨酸衍生物的分布的

公开(公告)号：EP2836513A1

公开(公告)日：2015-02-18

申请号：EP13785752.0

申请日：2013-10-18

申请人： AbbVie Inc.

发明人： SUBRAMANIAN, Kartik , PEREZ THIELE, Mayda , ZENG, Xiaobei , WONG, Chee, Furng , KAYMAKCALAN, Zehra , JING, Ying , CHUMSAE, Christopher

IPC分类号： C07K16/00 , C07K16/28 , C12N5/00

CPC分类号： C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00

摘要： The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.