发明公开
- 专利标题: PRODUCTION OF FUCOSYLATED GLYCOPROTEINS
- 专利标题(中): HERSTELLUNG VON FUCOSYLIERTEN GLYKOPROTEINEN
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申请号: EP13725617.8申请日: 2013-05-23
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公开(公告)号: EP2852610A1公开(公告)日: 2015-04-01
- 发明人: NATUNEN, Jari , WESTERHOLM-PARVINEN, Ann , SALO, Hanna , JOENSUU, Jussi , VISKARI, Heli , LANDOWSKI, Christopher , HUUSKONEN, Anne , KANERVA, Anne , HÄNNINEN, Anna-Liisa , SALOVUORI, Noora , PENTTILÄ, Merja , SAARINEN, Juhani , SALOHEIMO, Markku
- 申请人: Novartis AG , Glykos Finland Oy
- 申请人地址: Lichtstrasse 35 4056 Basel CH
- 专利权人: Novartis AG,Glykos Finland Oy
- 当前专利权人: Novartis AG,Glykos Finland Oy
- 当前专利权人地址: Lichtstrasse 35 4056 Basel CH
- 代理机构: Cabinet Plasseraud
- 优先权: US201261650910P 20120523
- 国际公布: WO2013174927 20131128
- 主分类号: C07K14/435
- IPC分类号: C07K14/435 ; C12P21/00 ; C12N9/10
摘要:
Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.
公开/授权文献
- EP2852610B1 PRODUCTION OF FUCOSYLATED GLYCOPROTEINS 公开/授权日:2018-07-11
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