发明公开
EP2855526A1 ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
审中-公开
单变量ANTI巨噬细胞甘露糖受体的网域瞄准和在肿瘤相关巨噬细胞体内成像
- 专利标题： ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
- 专利标题（中）： 单变量ANTI巨噬细胞甘露糖受体的网域瞄准和在肿瘤相关巨噬细胞体内成像
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申请号： EP13713373.2申请日： 2013-03-15
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公开(公告)号： EP2855526A1公开(公告)日： 2015-04-08
- 发明人: VAN GINDERACHTER, Jo , DE BAETSELIER, Patrick , DEVOOGDT, Nick , LAHOUTTE, Tony , LAOUI, Damya , MOVAHEDI, Kiavash , RAES, Geert , SCHOONOOGHE, Steve
- 申请人： VIB vzw , Vrije Universiteit Brussel
- 申请人地址： Rijvisschestraat 120 9052 Ghent BE
- 专利权人： VIB vzw,Vrije Universiteit Brussel
- 当前专利权人： VIB vzw,Vrije Universiteit Brussel
- 当前专利权人地址： Rijvisschestraat 120 9052 Ghent BE
- 优先权： US201213480350 20120524
- 国际公布： WO2013174537 20131128
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The present invention relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including nanobodies, against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
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