公开(公告)号：EP2968487B1

公开(公告)日：2019-01-30

申请号：EP14710327.9

申请日：2014-03-17

申请人： VIB VZW ,  Vrije Universiteit Brussel

发明人： DE BAETSELIER, Patrick ,  RAES, Geert ,  SCHOONOOGHE, Steve ,  DE VOS, Jens ,  LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  HERNOT, Sophie ,  BALA, Gezim ,  TIERENS, Simon

IPC分类号： A61K39/00 ,  C07K16/28

公开(公告)号：EP2855526A1

公开(公告)日：2015-04-08

申请号：EP13713373.2

申请日：2013-03-15

申请人： VIB vzw ,  Vrije Universiteit Brussel

发明人： VAN GINDERACHTER, Jo ,  DE BAETSELIER, Patrick ,  DEVOOGDT, Nick ,  LAHOUTTE, Tony ,  LAOUI, Damya ,  MOVAHEDI, Kiavash ,  RAES, Geert ,  SCHOONOOGHE, Steve

IPC分类号： C07K16/28

CPC分类号： A61K51/1027 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2317/22 ,  C07K2317/33 ,  C07K2317/569 ,  C07K2317/92

摘要： The present invention relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including nanobodies, against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.

公开(公告)号：EP2968487A1

公开(公告)日：2016-01-20

申请号：EP14710327.9

申请日：2014-03-17

申请人： VIB VZW ,  Vrije Universiteit Brussel

发明人： DE BAETSELIER, Patrick ,  RAES, Geert ,  SCHOONOOGHE, Steve ,  DE VOS, Jens ,  LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  HERNOT, Sophie ,  BALA, Gezim ,  TIERENS, Simon

IPC分类号： A61K39/00 ,  C07K16/28

CPC分类号： C07K16/2851 ,  A61B5/0033 ,  A61B5/0044 ,  A61B5/0073 ,  A61K39/3955 ,  A61K49/04 ,  A61K51/1027 ,  A61K51/1096 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.

公开(公告)号：EP3174559A1

公开(公告)日：2017-06-07

申请号：EP15744895.2

申请日：2015-07-17

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/1045 ,  A61K9/0019 ,  A61K51/1051 ,  A61K51/1069 ,  A61K51/1072 ,  A61K51/1078 ,  A61K51/1096 ,  C07K16/32 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V
HH ) or functional fragments thereof, wherein said V
HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions,for use in methods for the prevention and/or treatment of cancer.

摘要翻译： 本申请提供了多肽，其包含或基本上由重链抗体（VHH）或其功能性片段的至少一个重链可变结构域的其worin所述V HH或其功能性片段特异性地结合到靶蛋白确实是存在于和/或特定的 用于固体肿瘤或癌症细胞，例如，HER2。 本申请还提供编码检查的多肽的核酸; 用于制备寻求多肽的方法; 宿主细胞中表达或能够表达寻求的多肽; 组合物，并且具体地涉及药物组合物确实包括搜索多肽，核酸和/或宿主细胞。 本申请还提供搜索多肽，核酸，宿主细胞和/或组合物，用于预防和/或治疗癌症的方法中使用。

公开(公告)号：EP3718574A1

公开(公告)日：2020-10-07

申请号：EP20166462.0

申请日：2015-07-17

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

IPC分类号： A61K51/10 ,  A61P35/00

摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V HH ) or functional fragments thereof, wherein said V HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.

公开(公告)号：EP2748196B8

公开(公告)日：2016-11-30

申请号：EP12751318.2

申请日：2012-08-22

申请人： Université Grenoble Alpes ,  Centre Hospitalier Universitaire de Grenoble ,  Vrije Universiteit Brussel

发明人： GHEZZI, Catherine ,  FAGRET, Daniel ,  BROISAT, Alexis ,  DEVOOGDT, Nick ,  LAHOUTTE, Tony ,  MUYDERMANS, Serge

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P9/00

CPC分类号： C07K16/2803 ,  A61K51/1027 ,  C07K16/2836 ,  C07K2317/22 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6893

公开(公告)号：EP3325020A1

公开(公告)日：2018-05-30

申请号：EP16745643.3

申请日：2016-07-15

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  D'HUYVETTER, Matthias ,  DE VOS, Jens ,  DEVOOGDT, Nick

IPC分类号： A61K51/10 ,  C07K16/32 ,  A61K101/02 ,  A61K103/30 ,  A61P35/00

CPC分类号： A61K51/1096 ,  A61K51/1051 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/54 ,  A61P35/00 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569

摘要： Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (VHH), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the VHH, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.

公开(公告)号：EP3180037A1

公开(公告)日：2017-06-21

申请号：EP15749758.7

申请日：2015-07-29

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  KEYAERTS, Marleen

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/1051 ,  A61K51/1045 ,  A61K51/1069 ,  A61K51/1072 ,  A61K51/1078 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/32 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/57415 ,  G01N33/5748 ,  G01N2333/82

摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (VHH) or a functional fragment thereof, wherein said VHH or a functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions, that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for detection, imaging, prognosis and diagnosis of cancer as well as for predicting patient response(s) to therapeutics.

摘要翻译： 本申请提供了多肽，其包含或基本上由重链抗体（VHH）至少一个重链可变结构域或其功能片段的其worin所述V HH或其功能片段，其特异性地结合到靶蛋白确实是存在于和/ 或特异于固体肿瘤，例如 HER2。 本申请还提供编码检查的多肽的核酸; 用于制备寻求多肽的方法; 宿主细胞中表达或能够表达寻求的多肽; 组合物，特别是药物组合物，没有包括搜索多肽，核酸和/或宿主细胞。 本申请还提供搜索多肽，核酸，宿主细胞和/或组合物，在用于检测，成像，预后和以及预测患者反应（一个或多个），以治疗癌症的诊断方法中使用。