发明公开
- 专利标题： FLUORESCENT PROBE FOR HIGH-SENSITIVITY PANCREATIC FLUID DETECTION, AND METHOD FOR DETECTING PANCREATIC FLUID
- 专利标题（中）： 高灵敏度胰腺液检测用荧光探针及检测胰液的方法
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申请号： EP13797296.4申请日： 2013-05-29
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公开(公告)号： EP2857830A1公开(公告)日： 2015-04-08
- 发明人: URANO, Yasuteru , SAKABE, Masayo , NAGANO, Tetsuo , ISHIZAWA, Takeaki , YAMASHITA, Suguru , KOKUDO, Norihiro , KAMIYA, Mako
- 申请人： The University of Tokyo
- 申请人地址： 3-1, Hongo 7-chome Bunkyo-ku, Tokyo 113-8654 JP
- 专利权人： The University of Tokyo
- 当前专利权人： The University of Tokyo
- 当前专利权人地址： 3-1, Hongo 7-chome Bunkyo-ku, Tokyo 113-8654 JP
- 代理机构： Schüssler, Andrea
- 优先权： JP2012123478 20120530
- 国际公布： WO2013180181 20131205
- 主分类号： G01N21/78
- IPC分类号： G01N21/78 ; C07D493/10 ; C09K11/06 ; C12M1/00 ; C12M1/34 ; C12Q1/37 ; C12Q1/48 ; G01N21/64 ; C09B11/28
摘要：
[Problem]
To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe.
[Solution]
A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below.
(In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R 1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; and X represents a C 1 -C 3 alkylene group.)
To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe.
[Solution]
A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below.
(In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R 1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; and X represents a C 1 -C 3 alkylene group.)
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