发明授权
- 专利标题： FUSION POLYPEPTIDES COMPRISING MUCIN-DOMAIN POLYPEPTIDE LINKERS
- 专利标题（中）： 包含粘蛋白域多肽接头的融合多肽
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申请号： EP13800676.2申请日： 2013-06-06
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公开(公告)号： EP2858672B1公开(公告)日： 2018-04-04
- 发明人: ALVAREZ, Juan , MCSWEENEY, Leslie, A.
- 申请人： Alkermes, Inc.
- 申请人地址： 852 Winter Street Waltham, MA 02451 US
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： 852 Winter Street Waltham, MA 02451 US
- 代理机构： Lee, Nicholas John
- 优先权： US201261657264P 20120608; US201261657285P 20120608; US201261657378P 20120608; US201261723081P 20121106; US201361778812P 20130313; US201361778575P 20130313
- 国际公布： WO2013184938 20131212
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; C07K14/47
摘要：
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.
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