发明公开
EP2864296A1 2H-IMIDAZOL-4-AMINE COMPOUNDS AND THEIR USE AS BACE INHIBITORS
审中-公开
2H咪唑-4-胺化合物及其作为BACE抑制剂
- 专利标题: 2H-IMIDAZOL-4-AMINE COMPOUNDS AND THEIR USE AS BACE INHIBITORS
- 专利标题(中): 2H咪唑-4-胺化合物及其作为BACE抑制剂
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申请号: EP13731448.0申请日: 2013-06-20
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公开(公告)号: EP2864296A1公开(公告)日: 2015-04-29
- 发明人: KARLSTRÖM, Sofia , CSJERNYIK, Gabor , SWAHN, Britt-Marie , SANDBERG, Lars , KOLMODIN, Karin , SÖDERMAN, Peter , ÖHBERG, Liselotte
- 申请人: Astrazeneca AB
- 申请人地址: 151 85 Södertälje SE
- 专利权人: Astrazeneca AB
- 当前专利权人: Astrazeneca AB
- 当前专利权人地址: 151 85 Södertälje SE
- 代理机构: Curran, Clair
- 优先权: US201261661919P 20120620
- 国际公布: WO2013190298 20131227
- 主分类号: C07D235/02
- IPC分类号: C07D235/02 ; A61K31/4184 ; A61P25/28 ; C07D401/04 ; A61K31/4439
摘要:
2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration methods of therapy, and pharmaceutical compositions containing such compounds. Formula (I) wherein A is -O- or -CH
2 -, n is 1 or 1.
2 -, n is 1 or 1.
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