- 专利标题： GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS
-
申请号： EP13734062.6申请日： 2013-07-03
-
公开(公告)号： EP2870239B1公开(公告)日： 2018-10-31
- 发明人: BROCKMANN, Beata , HEROLD, Andrea , ZELDER, Oskar , HAEFNER, Stefan , FLECK, Christian , SCHRÖDER, Hartwig , GRANSTRÖM, Mari , SCHMIDT, Julia, Kristiane
- 申请人： Wintershall Holding GmbH , BASF SE
- 申请人地址： Friedrich-Ebert-Strasse 160 34119 Kassel DE
- 专利权人： Wintershall Holding GmbH,BASF SE
- 当前专利权人： Wintershall Holding GmbH,BASF SE
- 当前专利权人地址： Friedrich-Ebert-Strasse 160 34119 Kassel DE
- 代理机构： BASF IP Association
- 优先权： EP12174882 20120704
- 国际公布： WO2014006088 20140109
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12P19/04
摘要：
The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity or the use of such a polypeptide for producing &bgr;-glucans. Furthermore, the present invention relates to methods for producing &bgr;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity into a microorganism being able to synthesize &bgr;-glucans.
公开/授权文献
信息查询
