发明公开
EP2882706A1 AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
审中-公开
AMIN-ENTHALTENDE LIPIDOIDE UND DEREN VERWENDUNG
- 专利标题： AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
- 专利标题（中）： AMIN-ENTHALTENDE LIPIDOIDE UND DEREN VERWENDUNG
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申请号： EP13751043.4申请日： 2013-08-13
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公开(公告)号： EP2882706A1公开(公告)日： 2015-06-17
- 发明人: ANDERSON, Daniel, Griffith , WHITEHEAD, Kathryn, Ann , DORKIN, Joseph, R. , VEGAS, Arturo, Jose , ZHANG, Yunlong , LANGER, Robert, S.
- 申请人： Massachusetts Institute of Technology
- 申请人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US201261682468P 20120813
- 国际公布： WO2014028487 20140220
- 主分类号： C07C229/12
- IPC分类号： C07C229/12 ; C07C229/14 ; C07D295/13 ; C07D211/14 ; C07D319/18 ; C07D207/09 ; C07D211/26 ; C07D487/04 ; A61K47/18 ; A61K9/127 ; A61K9/51 ; A61K31/496 ; C12N15/11 ; C12N15/88
摘要：
Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
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