发明公开
EP2887959A4 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS
审中-公开
AN 158P1D7蛋白结合的抗体药物偶联物
- 专利标题： ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS
- 专利标题（中）： AN 158P1D7蛋白结合的抗体药物偶联物
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申请号： EP13831502申请日： 2013-08-23
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公开(公告)号： EP2887959A4公开(公告)日： 2016-03-23
- 发明人: MORRISON ROBERT KENDALL , AN ZILI , MORRISON KAREN JANE MEYRICK , SNYDER JOSH , JIA XIAO-CHI
- 申请人： AGENSYS INC , SEATTLE GENETICS INC
- 专利权人： AGENSYS INC,SEATTLE GENETICS INC
- 当前专利权人： AGENSYS INC,SEATTLE GENETICS INC
- 优先权： US201261692448 2012-08-23
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K39/395 ; A61P35/00 ; C07K16/18 ; C07K16/30 ; C12N5/071 ; C12P21/08
摘要：
Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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