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公开(公告)号：EP2887959A4
公开(公告)日：2016-03-23
申请号：EP13831502
申请日：2013-08-23
申请人： AGENSYS INC , SEATTLE GENETICS INC
CPC分类号： C07K16/30 , A61K45/06 , A61K47/48415 , A61K47/48438 , A61K47/48569 , A61K47/48584 , A61K47/48592 , A61K47/486 , A61K47/48607 , A61K47/48623 , A61K47/6811 , A61K47/6817 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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2.发明公开ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS 有权AN 191P4D12-PROTEINE BINDENDEANTIKÖRPER-WIRKSTOFFKONJUGATE
公开(公告)号：EP2621526A4
公开(公告)日：2014-06-04
申请号：EP11831345
申请日：2011-09-29
申请人： AGENSYS INC , SEATTLE GENETICS INC
发明人： SATPAEV DAULET , MORRISON ROBERT KENDALL , MORRISON KAREN JANE MEYRICK , GUDAS JEAN , JAKOBOVITS AYA , TORGOV MICHAEL , AN ZILI
IPC分类号： A61K39/00 , A61K39/395 , A61K47/48 , C07K1/00 , C07K16/30
CPC分类号： A61K47/48569 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：EP2403524A4
公开(公告)日：2012-09-26
申请号：EP10756560
申请日：2010-03-05
申请人： AGENSYS INC , SEATTLE GENETICS INC
发明人： GUDAS JEAN , JAKOBOVITS AYA , AN ZILI , MORRISON ROBERT KENDALL , MORRISON KAREN JANE MEYRICK , JIA XIAO-CHI , BENJAMIN DENNIS , MOSER RUTH , SENTER PETER
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
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4.发明公开NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 213P1F11 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开治疗和癌症SUITABLE NUCLEIC检测和相应的蛋白质与名称213P1F11
公开(公告)号：EP1578980A4
公开(公告)日：2013-01-02
申请号：EP02728647
申请日：2002-04-01
申请人： AGENSYS INC
发明人： CHALLITA-EID PIA M , RAITANO ARTHUR B , FARIS MARY , HUBERT RENE S , MORRISON ROBERT KENDALL , GE WANGMAO , JAKOBOVITS AYA
CPC分类号： C07K16/18 , A61K47/6851 , A61K2039/505 , C07K14/47 , C07K16/3015 , C07K16/3038 , C07K16/3069 , C07K2317/73 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be sued to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.
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5.发明公开NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 162P1E6 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开NUCLEIC与此相对应，162P1E6呼吁处理和检测步骤癌蛋白飞度
公开(公告)号：EP1573023A4
公开(公告)日：2008-09-03
申请号：EP02733973
申请日：2002-04-09
申请人： AGENSYS INC
发明人： CHALLITA-EID PIA M , RAITANO ARTHUR B , FARIS MARY , HUBERT RENE S , MORRISON KAREN , MORRISON ROBERT KENDALL , GE WANGMAO , JAKOBOVITS AYA
IPC分类号： C07K14/435 , A01K67/00 , A01K67/027 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/17 , A61K39/00 , A61K39/395 , A61K47/48 , A61K48/00 , A61K51/00 , A61M36/14 , A61P35/00 , C07H21/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K14/47 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/32 , C07K16/40 , C07K16/44 , C07K17/00 , C07K17/14 , C12N5/06 , C12N5/12 , C12N15/12 , C12N15/62 , C12Q20060101 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C07K14/4748 , A61K39/00 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
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6.发明公开NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 238P1B2 USEFUL IN TREATMENT AND DETECTION OF CANCER 有权NUCLEIC和使用名称238P1B2相应的蛋白质，适合治疗和癌症的检测
公开(公告)号：EP1553980A4
公开(公告)日：2006-06-14
申请号：EP02728645
申请日：2002-04-01
申请人： AGENSYS INC
发明人： RAITANO ARTHUR B , CHALLITA-EID PIA M , FARIS MARY , HUBERT RENE S , MORRISON ROBERT KENDALL , GE WANGMAO , JAKOBOVITS AYA
IPC分类号： C07K14/47 , C07K16/30 , A61K39/395 , A61K38/00 , A61K48/00 , C07H21/04 , C07K16/00 , C12N5/12 , C12P21/00 , C12Q1/68 , G01N33/543
CPC分类号： C07K14/47 , A61K39/395 , A61K2039/505 , C07K14/4748 , C07K16/3069 , A61K2300/00
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7.发明公开NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P5C5 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开NUCLEIC与此相对应，161P5C5呼吁处理和检测步骤癌蛋白飞度
公开(公告)号：EP1409710A4
公开(公告)日：2005-04-13
申请号：EP02728752
申请日：2002-04-09
申请人： AGENSYS INC
发明人： CHALLITA-EID PIA M , RAITANO ARTHUR B , FARIS MARY , HUBERT RENE S , MORRISON KAREN , MORRISON ROBERT KENDALL , GE WANGMAO , JAKOBOVITS AYA
IPC分类号： A01K67/00 , A01K67/027 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/17 , A61K39/00 , A61K39/395 , A61K47/48 , A61K48/00 , A61K51/00 , A61M36/14 , A61P35/00 , C07H21/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K14/47 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/32 , C07K16/40 , C07K16/44 , C07K17/00 , C07K17/14 , C12N5/06 , C12N5/12 , C12N15/12 , C12N15/62 , C12Q20060101 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C07K14/4748 , A61K39/00 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
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8.发明公开NULEIC ACIDS AND CORRESPONDING PROTEINS USEFUL IN THE DETECTION AND TREATMENT OF VARIOUS CANCERS 审中-公开NUCLEIC和THESE ENTPRECHENDE，各种癌症适合的蛋白质的治疗和检测
公开(公告)号：EP1573024A4
公开(公告)日：2007-08-29
申请号：EP02747813
申请日：2002-04-10
申请人： AGENSYS INC
发明人： JAKOBOVITS AYA , CHALLITA-EID PIA M , FARIS MARY , GE WANGMAO , HUBERT RENE S , MORRISON KAREN , MORRISON ROBERT KENDALL , RAITANO ARTHUR B
IPC分类号： A01K67/00 , A01K67/027 , A61K31/7088 , A61K38/17 , A61K38/46 , A61K39/395 , A61K47/48 , A61K48/00 , A61P35/00 , C07H21/04 , C07K5/00 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/12 , C12N15/12 , C12N15/62 , C12N15/63 , C12Q20060101 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/574 , A61K35/14 , A61K38/00 , C12N15/10 , C12N15/11 , C12N15/13 , G01N33/68
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
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9.发明公开NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER 有权NUCLEIC并用于治疗与名称125P5C8相应的蛋白质和癌症的检测
公开(公告)号：EP1372719A4
公开(公告)日：2007-02-07
申请号：EP02726630
申请日：2002-03-13
申请人： AGENSYS INC
发明人： FARIS MARY , CHALLITA-EID PIA M , HUBERT RENE S , AFAR DANIEL E H , RAITANO ARTHUR B , GE WANGMAO , MORRISON ROBERT KENDALL , MORRISON KAREN , JAKOBOVITS AYA
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; anti-bodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
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10.发明公开NUCLEIC ACIDS AND CORRESPONSING PROTEINS ENTITLED 101P3A11 OR PHOR-1 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开治疗和癌症SUITABLE NUCLEIC检测和相关蛋白与名称或101P3A11普-1
公开(公告)号：EP1539805A4
公开(公告)日：2005-11-16
申请号：EP02736898
申请日：2002-05-15
申请人： AGENSYS INC
发明人： JAKOBOVITS AYA , FARIS MARY , RAITANO ARTHUR B , MORRISON ROBERT KENDALL , SAFFRAN DOUGLAS , GE WANGMAO , CHALLITA-EID PIA M
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/28 , C07K16/46 , C12N5/06 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , C07K14/00 , C07H21/02 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47 , A61K2039/505 , C07K16/28 , C07K2317/34
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