发明公开
EP2890708A4 PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF
有权
甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
- 专利标题： PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF
- 专利标题（中）： 甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
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申请号： EP13832369申请日： 2013-08-28
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公开(公告)号： EP2890708A4公开(公告)日： 2016-06-08
- 发明人: DOSCHAK MICHAEL , YANG YANG , BHANDARI KRISHNA HARI
- 申请人： UNIV ALBERTA , DOSCHAK MICHAEL , YANG YANG , BHANDARI KRISHNA HARI
- 专利权人： UNIV ALBERTA,DOSCHAK MICHAEL,YANG YANG,BHANDARI KRISHNA HARI
- 当前专利权人： UNIV ALBERTA,DOSCHAK MICHAEL,YANG YANG,BHANDARI KRISHNA HARI
- 优先权： US201261693818 2012-08-28
- 主分类号： C07K14/65
- IPC分类号： C07K14/65 ; A61K38/28 ; A61K47/48 ; A61P19/08 ; C07K14/62 ; C07K14/635 ; C07K17/08 ; C08F299/02
摘要：
Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.
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