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1.发明公开PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF 有权甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
公开(公告)号：EP2890708A2
公开(公告)日：2015-07-08
申请号：EP13832369.6
申请日：2013-08-28
申请人： The Governors of the University of Alberta , Doschak, Michael , Yang, Yang , Bhandari, Krishna, Hari
CPC分类号： C07K14/62 , A61K31/663 , A61K38/29 , A61K47/548 , A61K47/60 , C07K14/635 , C07K14/65 , C08F299/02
摘要： Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate
de novo bone turnover and stimulate bone fracture repair.摘要翻译： 描述中是胰岛素与胰岛素样生长因子，甲状旁腺激素，甲状旁腺激素的片段，或副甲状腺激素相关蛋白并包括至少一个骨靶向部分，worin骨靶向部分共价键合到肽。 如此描述中的是制备合成的组合物也预防或治疗与骨损失和骨骨折预防相关的病症的方法，和/或无法启动从头骨转换，刺激骨折修复。
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2.发明公开PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF 有权甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
公开(公告)号：EP2890708A4
公开(公告)日：2016-06-08
申请号：EP13832369
申请日：2013-08-28
IPC分类号： C07K14/65 , A61K38/28 , A61K47/48 , A61P19/08 , C07K14/62 , C07K14/635 , C07K17/08 , C08F299/02
CPC分类号： C07K14/62 , A61K31/663 , A61K38/29 , A61K47/548 , A61K47/60 , C07K14/635 , C07K14/65 , C08F299/02
摘要： Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.
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公开(公告)号：EP2890708B1
公开(公告)日：2019-08-07
申请号：EP13832369.6
申请日：2013-08-28
申请人： The Governors of the University of Alberta , Doschak, Michael , Yang, Yang , Bhandari, Krishna, Hari
IPC分类号： A61K31/663 , A61K38/29 , A61K47/54 , A61K47/60 , C07K14/62 , C07K14/635 , C07K14/65 , C08F299/02
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