发明公开
EP2900671A1 SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
审中-公开
用于治疗过度增殖性疾病的取代的吲哚 - 吡咯并嘧啶类化合物
- 专利标题： SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
- 专利标题（中）： 用于治疗过度增殖性疾病的取代的吲哚 - 吡咯并嘧啶类化合物
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申请号： EP13766294.6申请日： 2013-09-23
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公开(公告)号： EP2900671A1公开(公告)日： 2015-08-05
- 发明人: KLAR, Ulrich , WORTMANN, Lars , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , PETERSEN, Kirstin , HÄGEBARTH, Andrea , SÜLZLE, Detlev , GRAHAM, Keith , RICHTER, Anja
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP12186032 20120926; EP13154193 20130206
- 国际公布： WO2014048869 20140403
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P35/00
摘要：
The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula (I):in which R
1a , R
1b , R
1c , R
1d , R
2a and R
2b are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
1a , R
1b , R
1c , R
1d , R
2a and R
2b are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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