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公开(公告)号：EP3250567B1
公开(公告)日：2019-10-30
申请号：EP16701600.5
申请日：2016-01-25
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SCHULZE, Volker , SIEMEISTER, Gerhard , LIENAU, Philip , TEMPEL, René , BÁLINT, Jozsef
IPC分类号： C07D405/14 , C07D401/12 , C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP2988787A1
公开(公告)日：2016-03-02
申请号：EP14719711.5
申请日：2014-04-22
发明人： BERGER, Markus , SÜLZLE, Detlev , FRENZEL, Thomas , GRAHAM, Keith , JOST, Gregor , NEIS, Christian , HEGETSCHWEILER, Kaspar , PIETSCH, Hubertus
CPC分类号： C07C229/76 , A61K49/0409 , C07C227/18 , C07C2601/14 , C07F7/00
摘要： The present invention describes a new class of trinuclear hafnium complexes comprising two hexadentate azainositol carboxylic acid ligands, methods for their preparation and their use as X-ray contrast agents and X-ray diagnostic agents. The claimed compounds can be described by the following Markush formula describing rinuclear hafnium complexes of general formula (I). The following is a compound according to the above Markush formula (example 8).
摘要翻译： 本发明描述了一类新的三核铪配合物，其包含两个六齿氮杂糖醇羧酸配体，它们的制备方法以及它们作为X射线造影剂和X射线诊断剂的用途。 要求保护的化合物可以通过描述通式（I）的核核铪配合物的以下马库舒公式描述。 以下是根据上述马库什公式（实施例8）的化合物。
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公开(公告)号：EP2454216A1
公开(公告)日：2012-05-23
申请号：EP10736610.6
申请日：2010-07-06
发明人： GRAHAM, Keith , BERNDT, Mathias , CHI, Dae, Yoon , LEE, Byoung, Se , SHINDE, Sandip, S. , KIL, Hee, Seup , LEE, Sang, Ju , RYU, Jin-Sook , OH, Seung, Jun
IPC分类号： C07B59/00 , C07D237/16 , C07D405/04 , C07D405/12 , C07D471/08 , C07D213/643
CPC分类号： C07B59/00 , C07C309/73 , C07C2601/14 , C07D213/643 , C07D237/16 , C07D405/04 , C07D405/12 , C07D471/08
摘要： The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group L
M , which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-L
M and by-products L
M .摘要翻译： 本发明提供了用于制备和纯化药物的新颖和有利的方法。该方法包括亲核反应，其中亲核反应中载体具有增加的亲脂性的改进的离去基团LM，其提供了方便和省时的方法来纯化 来自未反应的前体载体-ML和副产物LM的产物。
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公开(公告)号：EP4244225A1
公开(公告)日：2023-09-20
申请号：EP21830607.4
申请日：2021-11-09
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , MORTIER, Jeremie Xavier G. , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P35/02
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公开(公告)号：EP3157914B1
公开(公告)日：2018-09-26
申请号：EP15730130.0
申请日：2015-06-17
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , HITCHCOCK, Marion , BÄRFACKER, Lars , EIS, Knut , SCHULZE, Volker , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , HOLTON, Simon , LIENAU, Philip , TEMPEL, René , SONNENSCHEIN, Helmut , BÁLINT, Jozsef , GRAUBAUM, Heinz
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , A61K31/436 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/056
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP3250567A1
公开(公告)日：2017-12-06
申请号：EP16701600.5
申请日：2016-01-25
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SCHULZE, Volker , SIEMEISTER, Gerhard , LIENAU, Philip , TEMPEL, René , BÁLINT, Jozsef
IPC分类号： C07D405/14 , C07D401/12 , C07D471/04 , A61K31/437 , A61P35/00
摘要： Compounds of formula (I), processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2852596A1
公开(公告)日：2015-04-01
申请号：EP13725935.4
申请日：2013-05-17
发明人： KETTSCHAU, Georg , PÜHLER, Florian , EIS, Knut , KLAR, Ulrich , KOSEMUND, Dirk , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , BÖMER, Ulf , WORTMANN, Lars , GRAHAM, Keith , WENGNER, Antje Margret
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP2379757A2
公开(公告)日：2011-10-26
申请号：EP09798879.4
申请日：2009-12-12
发明人： GRAHAM, Keith , ROTHER, Axel , FRANCK , Dominic
CPC分类号： C22B3/42 , A61K51/04 , B01D15/16 , B01D15/325 , B01D15/362 , B01D15/363 , B01D15/424 , B01J20/285 , B01J20/287 , C22B3/24 , G01N30/32 , G01N2030/009 , Y02P10/234
摘要： The invention pertains to a method for eluting a radionuclide-label or a radionuclide-labeled compound using a solid phase extraction resin, to a device for performing such a method, and to a computer program for controlling such a device. Specifically, the method according to the invention enables the automated synthesis of a radionuclide-labeled compound using anion exchange resin or a reversed phase resin, and comprises the step of removing or eluting a radionuclide-label (f luorine-18, etc.) that is bound to an anion exchange resin, or a radionuclide-labeled compound that is bound to a reversed phase resin, by performing a ' 'pulsed' ' elution with an eluent.
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公开(公告)号：EP3700904A1
公开(公告)日：2020-09-02
申请号：EP18795421.9
申请日：2018-10-23
申请人： Bayer AG , BAYER PHARMA AKTIENGESELLSCHAFT , The Broad Institute, Inc. , Dana-Farber Cancer Institute Inc. et Al.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , KNUT, Eis , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , PETERSEN, Kirstin , MÖNNING, Ursula , EBERSPÄCHER, Uwe , MOOSMAYER, Dieter , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61P35/00 , A61K31/444 , A61K31/5377 , A61K31/4545
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公开(公告)号：EP3310775B1
公开(公告)日：2020-04-01
申请号：EP16734202.1
申请日：2016-06-14
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SIEMEISTER, Gerhard , MÖNNING, Ursula , BALINT, Jozsef
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P35/00
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