发明公开
EP2902403A1 CAPRAZENE-1'''-ESTERS AS ANTIBACTERIALS
审中-公开
CAPRAZEN-1“' - ESTER ALS ANTIBAKTERIELLE MITTEL
- 专利标题： CAPRAZENE-1'''-ESTERS AS ANTIBACTERIALS
- 专利标题（中）： CAPRAZEN-1“' - ESTER ALS ANTIBAKTERIELLE MITTEL
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申请号： EP14197812.2申请日： 2004-01-30
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公开(公告)号： EP2902403A1公开(公告)日： 2015-08-05
- 发明人: MIYAKE, Toshiaki , Igarashi, Masayuki , Shitara, Tetsuo , Takahashi, Yoshiaki , Hamada, Masa
- 申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI , Meiji Seika Pharma Co., Ltd.
- 申请人地址： 14-23, Kami Ohsaki 3-chome Shinagawa-ku, Tokyo 141-0021 JP
- 专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,Meiji Seika Pharma Co., Ltd.
- 当前专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,Meiji Seika Pharma Co., Ltd.
- 当前专利权人地址： 14-23, Kami Ohsaki 3-chome Shinagawa-ku, Tokyo 141-0021 JP
- 代理机构： Agasse, Stéphane
- 优先权： JP2003025323 20030131
- 主分类号： C07H19/06
- IPC分类号： C07H19/06 ; A61K31/7072 ; A61P31/04 ; A61P31/06 ; C07D405/14 ; C07D403/08 ; C07D403/14 ; C07H15/26 ; C07H19/067
摘要：
Caprazene-1"'-ester derivatives of the formula (III)
wherein Me is methyl group, R 2 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms or a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or an alkynyl group of 5-21 carbon atoms and A is hydrogen atom or an amino-protecting group which is an alkoxycarbonyl group or an aralkyloxycarbonyl group, or a pharmaceutically acceptable acid addition salt thereof.
The novel caprazene derivatives exhibit excellent antibacterial activities against a variety of bacteria including acid-fast bacteria.
wherein Me is methyl group, R 2 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms or a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or an alkynyl group of 5-21 carbon atoms and A is hydrogen atom or an amino-protecting group which is an alkoxycarbonyl group or an aralkyloxycarbonyl group, or a pharmaceutically acceptable acid addition salt thereof.
The novel caprazene derivatives exhibit excellent antibacterial activities against a variety of bacteria including acid-fast bacteria.
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