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18 条记录 (耗时 0.017 秒)

    Caprazene derivatives
    3.
    发明公开
    Caprazene derivatives 有权
    Caprazen-1“ - 在Derivate

    公开(公告)号：EP2527352A2

    公开(公告)日：2012-11-28

    申请号：EP12180101.3

    申请日：2004-01-30

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI ,  Meiji Seika Pharma Co., Ltd.

    发明人： Miyake, Toshiaki ,  Igarashi, Masayuki ,  Shitara, Tetsuo ,  Takahashi, Yoshiaki ,  Hamada, Masa

    IPC分类号： C07H19/06 ,  A61K31/7072 ,  A61P31/04 ,  A61P31/06

    CPC分类号： C07H19/067 ,  A61K31/7072 ,  C07D403/08 ,  C07D403/14 ,  C07D405/14 ,  C07H15/26 ,  C07H19/06 ,  Y02P20/55

    摘要： A caprazene-1"'-amide derivative and its 5"-N-alkoxycarbonyl or aralkyloxycarbonyl derivative which are represented by the following general formula (II)

    wherein Me is methyl group, R 1 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms, a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or a cycloalkyl group of 5-12 carbon atoms, or R 1 is a phenyl group having a straight chain alkyl group of 1-14 carbon atoms or a straight chain alkoxy group of 1-9 carbon atoms or a cycloalkyl group of 5-12 carbon atoms at the para-position of the phenyl group, A is hydrogen atom or A is an amino-protecting group including an alkoxycarbonyl group, particularly tert-butoxycarbonyl group, or an aralkyloxycarbonyl group, particularly benzyloxycarbonyl group, or a pharmaceutically acceptable acid addition salt thereof

    摘要翻译： 由以下通式（II）表示的癸酰-1“ - 酰胺衍生物及其5”-N-烷氧基羰基或芳烷氧基羰基衍生物，其中Me为甲基，R 1为直链或基本上直链的烷基 5-21个碳原子的直链或基本上直链的烯基或5-12个碳原子的环烷基，或者R 1是具有1-烷基的直链烷基的苯基， 14个碳原子或1-9个碳原子的直链烷氧基或5-12个碳原子的环烷基在苯基的对位，A是氢原子或A是包括烷氧基羰基的氨基保护基 基团，特别是叔丁氧基羰基或芳烷氧基羰基，特别是苄氧基羰基，或其药学上可接受的酸加成盐

    Caprazene derivatives
    7.
    发明公开
    Caprazene derivatives 有权
    Caprazene衍生物

    公开(公告)号：EP2527352A3

    公开(公告)日：2013-07-10

    申请号：EP12180101.3

    申请日：2004-01-30

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI ,  Meiji Seika Pharma Co., Ltd.

    发明人： Miyake, Toshiaki ,  Igarashi, Masayuki ,  Shitara, Tetsuo ,  Takahashi, Yoshiaki ,  Hamada, Masa

    IPC分类号： C07H19/06 ,  A61K31/7072 ,  A61P31/04 ,  A61P31/06

    CPC分类号： C07H19/067 ,  A61K31/7072 ,  C07D403/08 ,  C07D403/14 ,  C07D405/14 ,  C07H15/26 ,  C07H19/06 ,  Y02P20/55

    摘要： A caprazene-1"'-amide derivative and its 5"-N-alkoxycarbonyl or aralkyloxycarbonyl derivative which are represented by the following general formula (II)

    wherein Me is methyl group, R 1 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms, a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or a cycloalkyl group of 5-12 carbon atoms, or R 1 is a phenyl group having a straight chain alkyl group of 1-14 carbon atoms or a straight chain alkoxy group of 1-9 carbon atoms or a cycloalkyl group of 5-12 carbon atoms at the para-position of the phenyl group, A is hydrogen atom or A is an amino-protecting group including an alkoxycarbonyl group, particularly tert-butoxycarbonyl group, or an aralkyloxycarbonyl group, particularly benzyloxycarbonyl group, or a pharmaceutically acceptable acid addition salt thereof

    摘要翻译： 由以下通式（II）表示的Caprazene-1“ - 酰胺衍生物及其5”-N-烷氧基羰基或芳烷氧基羰基衍生物，其中Me是甲基，R 1是直链或基本上直链的 5-21个碳原子，5-21个碳原子的直链或基本上直链的链烯基或5-12个碳原子的环烷基，或者R1是具有1-14个碳原子的直链烷基的苯基 原子或1-9个碳原子的直链烷氧基或在苯基的对位具有5-12个碳原子的环烷基，A是氢原子或A是包括烷氧基羰基的氨基保护基团， 特别是叔丁氧基羰基或芳烷氧基羰基，特别是苄氧基羰基，或其药学上可接受的酸加成盐

    3'-Fluoro-3'-deoxykanamycin a and the production thereof
    9.
    发明公开
    3'-Fluoro-3'-deoxykanamycin a and the production thereof 失效
    3'-氟 - 3'-脱氧肉桂酸A及其生产方法

    公开(公告)号：EP0173614A3

    公开(公告)日：1986-08-13

    申请号：EP85401575

    申请日：1985-08-01

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

    发明人： Umezawa, Hamao ,  Umezawa, Sumio ,  Tsuchiya Tsutomu ,  Takahashi, Yoshiaki

    IPC分类号： C07H15/234 ,  A61K31/70 ,  C07H09/04

    CPC分类号： C07H15/234 ,  C07H9/04 ,  Y02P20/55

    摘要： A new compound, 3'-fluoro-3'-deoxykanamycin A is now provided, which is active against gram-negative and gram-positive bacteria, including kanamycin-resistant strains of bacteria and is useful as antibacterial agent for therapeutic treatment of bacterial infections. This new compound is produced by a process comprising reacting a 6- azido-2,4-di-O-protected-3,6-dideoxy-3-fluoro-α-D-glucopyranosyl bromide with the 4-hydroxyl group of a 6-0-(2'-0- protected-3'-N-protected-3'-amino-4',6'-di-O-protected-3'-deoxy-a-D-glucopyranosyl)-1,3-bis-N-protected-2-deoxystreptamine, reducing the azido group of the resulting reaction product into an amino group, and removing the remaining protective groups from the reduction product.

    2',3'-Dideoxy-2'-fluorokanamycin A and 1-N-(alpha-hydroxy-omega-aminoalkanoyl) derivatives thereof
    10.
    发明公开
    2',3'-Dideoxy-2'-fluorokanamycin A and 1-N-(alpha-hydroxy-omega-aminoalkanoyl) derivatives thereof 失效
    2'，3'-二脱氧-2'-氟卡那霉素-A和Seine 1-N-（α-羟基-ω-氨基烷酰基）-Derivate。

    公开(公告)号：EP0185323A2

    公开(公告)日：1986-06-25

    申请号：EP85115901.2

    申请日：1985-12-13

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

    发明人： Umezawa, Hamao ,  Umezawa, Sumio ,  Tsuchiya, Tsutomu ,  Takahashi, Yoshiaki

    IPC分类号： C07H15/236 ,  C07H15/234 ,  A61K31/70

    CPC分类号： C07H15/234 ,  Y02P20/55

    摘要： New compounds, 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(a-hydroxy-w-aminoalkanoyl) derivatives thereof, particularly 1-N-(DL- or L-3-amino-2-hydroxypropionyl)- and 1-N-(L-4-amino-2-hydroxybutyryt)-2',3'-dideoxy-2'-fluorokanamycins A are now provided, which are each useful as anti-bacterial agent. 2',3'-Dideoxy-2'-fluorokanamycin A is prepared by a process comprising condensing a 6-azido-4-0-protected-2,3-6-trideoxy-2-fluoro-a-D-ribo-hexopyranosyl bromide with the 4-hydroxyl group of a 6-0-(2',4',6'-tri-0- protected-3'-N-protected-3'-amino-3'-deoxy-α-D-glucopyranosyl)-1,3-bis-N-protected-2-deoxystreptamine, reducing the resulting condensation product to convert its azido group into an amino group, and removing the remaining amino-protecting and hydroxyl-protecting groups from the reduction product.