发明公开
- 专利标题： SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS
- 专利标题（中）： 取代的三唑和咪唑
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申请号： EP13796097.7申请日： 2013-11-29
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公开(公告)号： EP2925746A1公开(公告)日： 2015-10-07
- 发明人: LYNCH, Stephen M. , MARTIN, Rainer E. , NEIDHART, Werner , PLANCHER, Jean-Marc , SCHULZ-GASCH, Tanja
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Haefele Racin, Thomas
- 优先权： US201261732454P 20121203
- 国际公布： WO2014086663 20140612
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; A61K31/415 ; A61K31/4164 ; A61K31/4192 ; A61K31/4196 ; C07D233/90 ; C07D401/12 ; C07D403/06 ; C07D405/12 ; C07D409/12 ; C07D249/04 ; C07D249/10 ; A61P19/02 ; A61P1/00
摘要：
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.
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