发明公开
EP2926830A3 Human immunodeficiency virus (HIV)-neutralizing antibodies
有权
安非他明（Zur Neutralisierung des humanen Immundefizienz-Virus（HIV）
- 专利标题： Human immunodeficiency virus (HIV)-neutralizing antibodies
- 专利标题（中）： 安非他明（Zur Neutralisierung des humanen Immundefizienz-Virus（HIV）
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申请号： EP14004015.5申请日： 2011-08-31
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公开(公告)号： EP2926830A3公开(公告)日： 2015-11-11
- 发明人: Chan-Hui, Po-Ying , Doores, Katherine , Huber, Michael , Kaminsky, Stephen , Frey, Steven , Olsen, Ole , Mitcham, Jennifer , Moyle, Matthew , Phogat, Sanjay K. , Burton, Dennis R. , Walker, Laura Marjorie , Poignard, Pascal Raymond Georges , Koff, Wayne , Simek-Lemos, Melissa Danielle ...
- 申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International Aids Vaccine Initiative
- 申请人地址： 1124 Columbia Street, Suite 300 Seattle, WA 98104 US
- 专利权人： Theraclone Sciences, Inc.,The Scripps Research Institute,International Aids Vaccine Initiative
- 当前专利权人： Theraclone Sciences, Inc.,The Scripps Research Institute,International Aids Vaccine Initiative
- 当前专利权人地址： 1124 Columbia Street, Suite 300 Seattle, WA 98104 US
- 代理机构： Schüssler, Andrea
- 优先权： US378604P 20100831; US386940P 20100927; US201161476978P 20110419; US201161515548P 20110805
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/10
摘要：
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
公开/授权文献
- EP2926830B1 HUMAN IMMUNODEFICIENCY VIRUS (HIV)-NEUTRALIZING ANTIBODIES 公开/授权日：2017-08-02
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