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发明公开
EP2927321A1 CH3 DOMAIN VARIANT PAIR INDUCING FORMATION OF HETERODIMER OF HEAVY CHAIN CONSTANT REGION OF ANTIBODY AT HIGH EFFICIENCY, METHOD FOR PREPARING SAME, AND USE THEREOF 审中-公开
CH3域选项FEW对诱导恒异源二聚体重链的抗体区AT高精度法的形成用于其和使用及其生产

CH3 DOMAIN VARIANT PAIR INDUCING FORMATION OF HETERODIMER OF HEAVY CHAIN CONSTANT REGION OF ANTIBODY AT HIGH EFFICIENCY, METHOD FOR PREPARING SAME, AND USE THEREOF
摘要：
The present invention relates to a CH3 domain variant pair of an antibody, to a method for preparing same, and to a use thereof, wherein a mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer according to the present invention, forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer of the present invention, and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.
摘要（中）：

本发明涉及到CH3结构域的变体对的抗体，涉及一种制备方法，以及它们的用途，worin突变在CH3结构域诱导的，从而改善形成的异源二聚体重链恒定区的屈服 的抗体。 CH3结构域的异源二聚体gemäß到本发明中，形成异源二聚体重链恒定区具有90％至95％以上的高效率，并因此具有优异的热稳定性。 甲异二聚体重链恒定区包含CH3结构域的异源二聚体可以构建双特异性单克隆抗体，其同时识别两种种抗原。 本发明的CH3结构域的异源二聚体，和抗体恒定区，其包含相同的双特异性抗体或融合蛋白可有效地应用于具有靶抗原或靶蛋白相关的疾病的治疗或预防。

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