发明公开
- 专利标题： MANUFACTURING PROCESS FOR MEMANTINE
- 专利标题（中）： VERFAHREN ZUR HERSTELLUNG VON MEMANTIN
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申请号： EP14743873.3申请日： 2014-01-16
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公开(公告)号： EP2949643A1公开(公告)日： 2015-12-02
- 发明人: SHIMO, Tetsuya
- 申请人： Mitsubishi Gas Chemical Company, Inc.
- 申请人地址： 5-2, Marunouchi 2-chome Chiyoda-ku Tokyo 100-8324 JP
- 专利权人： Mitsubishi Gas Chemical Company, Inc.
- 当前专利权人： Mitsubishi Gas Chemical Company, Inc.
- 当前专利权人地址： 5-2, Marunouchi 2-chome Chiyoda-ku Tokyo 100-8324 JP
- 代理机构： Müller-Boré & Partner Patentanwälte PartG mbB
- 优先权： JP2013010125 20130123
- 国际公布： WO2014115638 20140731
- 主分类号： C07C209/62
- IPC分类号： C07C209/62 ; C07C211/38 ; C07C231/06 ; C07C233/06
摘要：
A method for manufacturing 3,5-dimethyl-1-adamantanamine of the present invention comprises: (i) a step of reacting 3,5-dimethyl-1-adamantanol with an acid and nitrile in an organic solvent to obtain a reaction solution; (ii) a step of adding water to the reaction solution obtained in step (i) to obtain 1-amido-3,5-dimethyladamantane; and (iii) a step of hydrolyzing 1-amido-3,5-dimethyladamantane obtained in step (ii) in the presence of an alcohol-containing solvent and an inorganic base.
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