发明公开
- 专利标题： AMIDOIMIDAZOPYRIDAZINES AS MKNK-1 KINASE INHIBITORS
- 专利标题（中）： 作为MKNK-1激酶抑制剂的氨基咪唑哒嗪
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申请号： EP14701976.4申请日： 2014-01-28
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公开(公告)号： EP2951181A1公开(公告)日： 2015-12-09
- 发明人: ZORN, Ludwig , EIS, Knut , SCHULZE, Volker , SÜLZLE, Detlev , PÜHLER, Florian , LIENAU, Philip , BÖMER, Ulf , PETERSEN, Kirstin , HÄGEBARTH, Andrea
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP13153340 20130130
- 国际公布： WO2014118135 20140807
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D491/04 ; A61K31/5025 ; A61P35/00 ; A61P29/00 ; A61P37/00
摘要：
The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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