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公开(公告)号：EP4260909A3
公开(公告)日：2024-03-20
申请号：EP23189515.2
申请日：2015-11-25
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , NUBBEMEYER, Reinhard , BÖMER, Ulf , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , STEGMANN, Christian , SUTTER, Andreas , RAUSCH, Alexandra , FRIEDRICH, Christian , HAUFF, Peter
IPC分类号： A61P35/00 , A61P19/02 , A61P9/00 , A61P17/00 , A61P29/00 , C07D401/12 , C07D405/14 , A61K31/4439
摘要： Die vorliegende Anmeldung betrifft neue substituierte Indazole, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prophylaxe von Endometriose sowie Endometriose-assoziierter Schmerzen und anderer Endometriose-assoziierter Symptome wie Dysmenorrhoe, Dyspareunie, Dysurie und Dyschezie, von Lymphomen, Rheumatoider Arthritis, Spondyloarthritiden (insbesondere Spondyloarthritis psoriatica und Morbus Bechterew), Lupus erythematodes, Multipler Sklerosis, Makuladegeneration, COPD, Gicht, Fettlebererkrankungen, Insulinresistenz, Tumorerkrankungen und Psoriasis.
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公开(公告)号：EP3402795B1
公开(公告)日：2019-10-30
申请号：EP17700500.6
申请日：2017-01-06
发明人： LÜCKING, Ulrich , KOPPITZ, Marcus , LEFRANC, Julien , WORTMANN, Lars , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BÖMER, Ulf , BADER, Benjamin , LIENAU, Philip , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
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公开(公告)号：EP3129387B1
公开(公告)日：2019-06-26
申请号：EP15715715.7
申请日：2015-04-08
发明人： LÜCKING, Ulrich , WASNAIRE, Pierre , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , STEGMANN, Christian , BÖMER, Ulf , ZHENG, Kunzeng , GAO, Ping , CHEN, Gang , XI, Jiajun
IPC分类号： C07D498/14 , A61K31/529 , A61P35/00
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP2699554B1
公开(公告)日：2016-11-02
申请号：EP12714336.0
申请日：2012-04-18
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten , KOSEMUND, Dirk , LIENAU, Philip
IPC分类号： C07D401/12 , C07D405/04 , C07D251/42 , C07D401/04 , C07D405/12
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
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公开(公告)号：EP2852595B1
公开(公告)日：2016-06-22
申请号：EP13723163.5
申请日：2013-05-17
发明人： KLAR, Ulrich , KETTSCHAU, Georg , KOSEMUND, Dirk , PÜHLER, Florian , EIS, Knut , LIENAU, Philip , BÖMER, Ulf , SÜLZLE, Detlev , WORTMANN, Lars
IPC分类号： C07D495/04 , A61K31/38 , A61P35/00
CPC分类号： C07D495/04 , A61K31/38 , A61K31/519 , A61K45/06 , C07D519/00
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7.发明授权DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS 有权二取代噻吩基吡咯并三及其作为FGFR激酶抑制剂
公开(公告)号：EP2791140B1
公开(公告)日：2016-06-15
申请号：EP12798738.6
申请日：2012-12-10
发明人： BROHM, Dirk , HEROULT, Melanie , COLLIN, Marie-Pierre , HÜBSCH, Walter , LOBELL, Mario , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
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公开(公告)号：EP2920176A1
公开(公告)日：2015-09-23
申请号：EP13795702.3
申请日：2013-11-14
发明人： ZORN, Ludwig , EIS, Knut , SCHULZE, Volker , SÜLZLE, Detlev , PÜHLER, Florian , LIENAU, Philip , BÖMER, Ulf , PETERSEN, Kirstin , HÄGEBARTH, Andrea
IPC分类号： C07D487/04 , A61K31/4355 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , C07D519/00
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物，其中A，R 1，R 2，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂的用途或 与其他活性成分组合。
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9.发明公开N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权N-（吡啶-2-基）吡啶并[4-AMIN-DERIVATE MIT EINER SULFOXIMINGRUPPE]
公开(公告)号：EP2920164A1
公开(公告)日：2015-09-23
申请号：EP13794844.4
申请日：2013-11-13
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D401/12 , A61K31/506 , A61P9/00 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506
摘要： The present invention relates to disubstituted N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/ or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的磺酰亚胺基的二取代的N-（吡啶-2-基）嘧啶-4-胺衍生物及其制备方法及其用于治疗和/ 或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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10.发明公开N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权甲砜基团含有N-（吡啶-2-基）嘧啶-4-胺衍生物
公开(公告)号：EP2909200A2
公开(公告)日：2015-08-26
申请号：EP13777070.7
申请日：2013-10-16
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D405/14 , C07D401/12 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506 , A61K45/06 , C07D207/44 , C07D233/88 , C07D405/14 , A61K2300/00
摘要： The present invention relates to N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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