发明公开
EP2954050A2 IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME
审中-公开
改进的杆状病毒表达系统和方法及其制造
- 专利标题： IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME
- 专利标题（中）： 改进的杆状病毒表达系统和方法及其制造
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申请号： EP14708951.0申请日： 2014-02-10
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公开(公告)号： EP2954050A2公开(公告)日： 2015-12-16
- 发明人: BERGER, Imre , THIMIRI GOVINDA RAJ, Deepak Balaji
- 申请人： European Molecular Biology Laboratory
- 申请人地址： Meyerhofstrasse 1 69117 Heidelberg DE
- 专利权人： European Molecular Biology Laboratory
- 当前专利权人： European Molecular Biology Laboratory
- 当前专利权人地址： Meyerhofstrasse 1 69117 Heidelberg DE
- 代理机构： Zwicker, Jörk
- 优先权： US201361762607P 20130208
- 国际公布： WO2014122629 20140814
- 主分类号： C12N7/00
- IPC分类号： C12N7/00
摘要：
The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade Ia viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade Ia genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade Ia genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.
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