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公开(公告)号:EP4368195A1
公开(公告)日:2024-05-15
申请号:EP22207154.0
申请日:2022-11-14
IPC分类号: A61K38/14 , A61K31/505 , A61K31/519 , A61K31/7036 , A61K45/06 , A61P31/04
CPC分类号: A61K45/06 , A61K38/14 , A61K31/505 , A61K2300/0020130101 , A61K31/519 , A61K31/7036 , A61P31/04
摘要: The present invention relates to the field of therapeutics and in particular to pharmaceutical compositions for the prevention and/or treatment of bacterial infections. The compositions of the present invention demonstrate a synergistic effect in inhibiting the growth of the most clinically relevant Gram-positive bacterial species, and resistant clinical isolates thereof (e.g. MRSA). The two combinations illustrate two novel principles in antimicrobial treatments, using non-antibiotic drugs as adjuvants and decoupling known fixed-dose combinations to repurpose their individual members in novel combinations. The combinations demonstrated a strong synergistic inhibitory effect on the growth, the killing activity and the in vivo infection outcome of clinically relevant Gram-positive pathogens, such as MRSA. Importantly, this invention relates to combinations that target multi-drug resistant strains, constituting a major effort of antimicrobial therapy development in the current antimicrobial resistance crisis.
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公开(公告)号:EP4235255A2
公开(公告)日:2023-08-30
申请号:EP23171141.7
申请日:2014-04-08
IPC分类号: G02B21/36
摘要: An optical arrangement (10) for imaging a sample (20) comprises at least one first objective lens (30) and at least one second objective lens (40); at least one illumination source (50) for producing an illumination beam (60); a detector (70) for imaging radiation (80) from the sample (20); and at least one mirror (90a, 90b, 90c) for reflecting the radiation (80) from one of the first objective lens (30) or the second objective lens (40) into the detector (70), wherein the position of the at least one mirror (90a, 90b, 90c) is dependent on the illumination beam (60) at the other one of the at least one first objective lens (30) and the at least one second objective lens (40).
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公开(公告)号:EP4085065A1
公开(公告)日:2022-11-09
申请号:EP20839078.1
申请日:2020-12-22
IPC分类号: C07K14/195 , C07K14/35
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公开(公告)号:EP3784223A1
公开(公告)日:2021-03-03
申请号:EP19720499.3
申请日:2019-04-17
IPC分类号: A61K31/11 , A61K31/12 , A61K31/395 , A61K31/7036 , A61P31/04 , A61K38/12
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公开(公告)号:EP3638664A1
公开(公告)日:2020-04-22
申请号:EP18732031.2
申请日:2018-06-14
IPC分类号: C07D407/12 , A61K31/343 , A61K31/4168 , A61K31/422 , A61K31/427 , C07D413/12 , C07D417/12 , C07D417/14 , A61P17/06 , A61P17/14 , A61P29/00 , A61P35/00
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公开(公告)号:EP3158081B1
公开(公告)日:2019-12-25
申请号:EP15729200.4
申请日:2015-06-18
发明人: BERGER, Imre , PELOSSE, Martin , SCHLATTNER, Uwe
IPC分类号: C12Q1/48 , G01N33/542 , C12N9/12 , G01N33/50
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公开(公告)号:EP3495865A1
公开(公告)日:2019-06-12
申请号:EP17205938.8
申请日:2017-12-07
摘要: A sample holder (5) comprises one or more elongated sample tubes (15). The one or more elongated sample tubes (15) are adapted for accommodating a plurality of samples (16) to be imaged at an imaging position (25). The imaging position (25) is defined by at least one illumination objective lens (20A, 20B) and at least one detection objective lens (30) of a microscope (100). A microscope (100) is disclosed, comprising at least one illumination objective lens (20A, 20B) and at least one detection objective lens (30), which define an imaging position (25). The microscope (100) further comprises a sample holder (5) for holding (225) a plurality of samples (16). The sample holder (5) is moveable with respect to the imaging position (25). A method for imaging (700) a plurality of samples (16) by means of the microscope (100) is disclosed.
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公开(公告)号:EP3475423A1
公开(公告)日:2019-05-01
申请号:EP17728108.6
申请日:2017-05-29
IPC分类号: C12N15/11 , C12N15/113 , A61K31/712 , C12Q1/68
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公开(公告)号:EP3436591A1
公开(公告)日:2019-02-06
申请号:EP17715444.0
申请日:2017-03-31
申请人: The European Molecular Biology Laboratory , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: BERGER, Imre , GARZONI, Frédéric , FENDER, Pascal
IPC分类号: C12N15/86 , C07K14/005 , C12N7/00 , A61K39/12
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