A method for manufacturing a waterproof and vapor-permeable shoe (1) (20) (30) (40) (50) comprising the steps of providing an upper (2) and a lining (3) comprising at least one functional layer (7) of vapor-permeable and waterproof material, providing an insole (5) comprising a functional support sheet (9) of vapor-permeable and waterproof material, coupling the peripheral edge of the functional layer (7) of the lining (3) to the peripheral edge of the functional sheet (9) of the insole (5) by way of a sealing waterproof adhesive (8) so as to shape a sock of vapor-permeable and waterproof material, couple the upper (2) to the outer surface of the lining (3) by way of a vapor-permeable adhesive; and couple a sole (4) to the upper (2) and/or to the lining (3) and/or to the insole (5).