发明公开
EP2961849A2 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF
审中-公开
T-电芯平衡基因表达，材料组成和及其使用方法
- 专利标题： T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF
- 专利标题（中）： T-电芯平衡基因表达，材料组成和及其使用方法
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申请号： EP14715725.9申请日： 2014-02-27
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公开(公告)号： EP2961849A2公开(公告)日： 2016-01-06
- 发明人: REGEV, Aviv , KUCHROO, Vijay , PARK, Hongkun , YOSEF, Nir , SHALEK, Alexander, K. , GAUBLOMME, Jellert , JOLLER, Nicole C. , WU, Chuan , ANDERSON, Ana, Carrizosa
- 申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , Massachusetts Institute of Technology
- 申请人地址： 415 Main Street Cambridge, MA 02142 US
- 专利权人： The Broad Institute, Inc.,President and Fellows of Harvard College,The Brigham and Women's Hospital, Inc.,Massachusetts Institute of Technology
- 当前专利权人： The Broad Institute, Inc.,President and Fellows of Harvard College,The Brigham and Women's Hospital, Inc.,Massachusetts Institute of Technology
- 当前专利权人地址： 415 Main Street Cambridge, MA 02142 US
- 代理机构： Cabinet Plasseraud
- 优先权： US201361770036P 20130227
- 国际公布： WO2014134351 20140904
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A61K39/39 ; C12N5/0783
摘要：
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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