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1.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T-ZELLEN-BALANCE-GENEXPRESSSION，MATERIALZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP3110971A2
公开(公告)日：2017-01-04
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/68
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
摘要翻译： 本发明一般涉及用于鉴定调节，控制或以其它方式影响T细胞平衡的调节网络的组合物和方法，例如Th17细胞分化，维持和/或功能，以及用于利用调节网络的组合物和方法， 控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡。 本发明还涉及鉴定和利用调节，控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡的靶基因和/或靶基因产物。
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2.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T-电芯平衡基因表达，材料组成和及其使用方法
公开(公告)号：EP2961849A2
公开(公告)日：2016-01-06
申请号：EP14715725.9
申请日：2014-02-27
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , Massachusetts Institute of Technology
发明人： REGEV, Aviv , KUCHROO, Vijay , PARK, Hongkun , YOSEF, Nir , SHALEK, Alexander, K. , GAUBLOMME, Jellert , JOLLER, Nicole C. , WU, Chuan , ANDERSON, Ana, Carrizosa
IPC分类号： C12Q1/68 , A61K39/39 , C12N5/0783
CPC分类号： C12N5/0636 , A61K31/12 , A61K31/198 , A61K31/37 , A61K31/4745 , A61K31/66 , A61K31/661 , A61K31/7076 , A61K31/7088 , A61K31/739 , A61K33/00 , A61K33/06 , A61K33/24 , A61K38/1767 , A61K38/1866 , A61K38/191 , A61K38/363 , A61K38/4866 , A61K48/00 , C07K16/28 , C07K2317/76 , C12N5/0637 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12N2501/15 , C12N2501/2301 , C12N2501/2306 , C12N2501/2323 , C12N2501/25 , C12N2501/90 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y304/21069 , G01N33/56972 , G01N2570/00 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP3110971B1
公开(公告)日：2019-05-08
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/6883 , C07K16/28 , G01N33/68
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4.发明公开A DROPLET-BASED METHOD AND APPARATUS FOR COMPOSITE SINGLE-CELL NUCLEIC ACID ANALYSIS 审中-公开基于液滴法的复合单细胞核酸分析方法及装置
公开(公告)号：EP3191605A1
公开(公告)日：2017-07-19
申请号：EP15767655.2
申请日：2015-09-09
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： REGEV, Aviv , MACOSKO, Evan, Zane , MCCARROLL, Steven, Andrew , SHALEK, Alexander, K. , BASU, Anindita , FORD, Christopher, B. , PARK, Hongkun , WEITZ, David, A.
CPC分类号： C12Q1/6809 , C12N15/1096 , C12Q1/6834 , C12Q1/6869 , G06K19/06 , C12Q2521/107 , C12Q2525/15 , C12Q2525/155 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629 , C12Q2563/179
摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
摘要翻译： 本发明总体上涉及分子条形码和基于乳液的微流体的组合，以高通量方式分离，裂解，条形码并从各个细胞制备核酸。
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5.发明公开DENDRITIC CELL RESPONSE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开反应树突状细胞，燃料组合物以及它们的用途方法基因表达
公开(公告)号：EP2971116A1
公开(公告)日：2016-01-20
申请号：EP14762551.1
申请日：2014-03-17
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/02 , A61K39/395
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/5047 , G01N33/6893 , G01N2800/24
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP4232012A1
公开(公告)日：2023-08-30
申请号：EP21884062.7
申请日：2021-10-25
IPC分类号： A61K31/015 , A61K31/047 , A61K31/706 , A61K31/7068 , C12N5/071 , C12N5/074
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7.发明公开TUMOR AND MICROENVIRONMENT GENE EXPRESSION, COMPOSITIONS OF MATTER AND METHODS OF USE THEREOF 审中-公开肿瘤和微环境基因表达，物质组成和使用方法
公开(公告)号：EP3314020A1
公开(公告)日：2018-05-02
申请号：EP16741186.7
申请日：2016-06-29
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation , Garraway, Levi A. , Izar, Benjamin , Prakadan, Sanjay , Regev, Aviv , Rozenblatt-Rosen, Orit , Shalek, Alexander K. , Suva, Mario , Tirosh, Itay , Venteicher, Andrew , Wadsworth, Marc II , Bernstein, Bradley , Parikh, Anuraag , Puram, Sidharth
发明人： GARRAWAY, Levi, A. , IZAR, Benjamin , PRAKADAN, Sanjay , REGEV, Aviv , ROZENBLATT-ROSEN, Orit , SHALEK, Alexander, K. , SUVA, Mario , TIROSH, Itay , VENTEICHER, Andrew , WADSWORTH, Marc, II , BERNSTEIN, Bradley , PARIKH, Anuraag , PURAM, Sidharth
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. The invention also relates to the modulation of complement activity to shift cellular immunity and obtain an effective therapeutic response.
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公开(公告)号：EP2888048A1
公开(公告)日：2015-07-01
申请号：EP13717359.7
申请日：2013-03-15
CPC分类号： B81C1/00111 , B01L3/5085 , B01L99/00 , B01L2300/0851 , B01L2300/0896 , B01L2300/163 , B01L2400/086 , B81B7/04 , B81B2201/055 , B81B2203/0361 , B81B2207/056 , B82Y15/00 , B82Y30/00 , C12M23/12 , C12M25/00 , C12N1/20 , C12N5/0068 , Y10T156/10
摘要： The present invention generally relates to nanowires and, in particular, to multiwell plates comprising nanowires, including systems and methods of making the same. Such multiwell plates can, in some cases, be used in automated equipment or high-throughput applications. For example, a plurality of cells may be placed in at least some of the wells of the multiwell plate, and one or more nanowires may be inserted into at least some of the cells within the wells of the multiwell plate. In some cases, one or more of the nanowires may have coated thereon a biological effector. The cells in each of the wells may be identical or different, and/or the biological effector may the same or different. Such multiwell plates may be used, for example, to test a biological effector against a variety of cell types, or to test a variety of biological effectors against a one or more cell types, or the like.
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公开(公告)号：EP2888047A1
公开(公告)日：2015-07-01
申请号：EP13715062.9
申请日：2013-03-15
CPC分类号： B81C1/00111 , B01L3/5085 , B01L99/00 , B01L2300/0851 , B01L2300/0896 , B01L2300/163 , B01L2400/086 , B81B7/04 , B81B2201/055 , B81B2203/0361 , B81B2207/056 , B82Y15/00 , B82Y30/00 , C12M23/12 , C12M25/00 , C12N1/20 , C12N5/0068 , Y10T156/10
摘要： The present invention generally relates to nanowire arrays and methods of fabricating such arrays. In certain embodiments, the fabrication methods can consistently form NW arrays with reproducible configurations at nanoscale sites and produce NWs of specified heights, diameters, and densities. In some cases, the methods also allow formation of NW arrays containing barriers between regions, which would be prohibitively expensive if prepared by other methods.
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公开(公告)号：EP3402902A2
公开(公告)日：2018-11-21
申请号：EP17705198.4
申请日：2017-01-17
发明人： GIERAHN, Todd M. , LOVE, Christopher J. , HUGHES, Travis, K. , WADSWORTH, Marc, H , SHALEK, Alexander, K. , CARROLL, Shaina
CPC分类号： C12Q1/6874 , C12Q2537/143 , C12Q2563/149 , C12Q2563/179 , C12Q2565/514
摘要： The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising performing molecular bonding of a porous membrane on an apical or basal surface of an array having a plurality of wells, wherein the molecular bonding substantially isolates each well from adjacent wells.
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