发明公开
- 专利标题: COMMON LIGHT CHAIN MOUSE
- 专利标题(中): 鼠标与普通的轻链
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申请号: EP14722432.3申请日: 2014-03-13
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公开(公告)号: EP2970437A1公开(公告)日: 2016-01-20
- 发明人: BABB, Robert , MCWHIRTER, John , MACDONALD, Lynn , STEVENS, Sean , DAVIS, Samuel , BUCKLER, David R. , MEAGHER, Karolina A. , MURPHY, Andrew J. , LEVENKOVA, Natasha
- 申请人: Regeneron Pharmaceuticals, Inc.
- 申请人地址: 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 专利权人: Regeneron Pharmaceuticals, Inc.
- 当前专利权人: Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址: 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 代理机构: Power, David
- 优先权: US201313798310 20130313
- 国际公布: WO2014160179 20141002
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C07K16/46 ; A01K67/027 ; C12N15/85
摘要:
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.
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