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公开(公告)号：EP4134378A1
公开(公告)日：2023-02-15
申请号：EP22199396.7
申请日：2015-11-13
发明人： CHEN, Gang , BABB, Robert , FANDL, James, P.
IPC分类号： C07K16/00 , C07K16/22 , C07K16/32 , G01N33/50 , C12N5/0781
摘要： The present disclosure relates to a method for identifying cells that express antigen-specific antibodies with a high binding affinity for a monomeric antigen. Using fluorescence activated cell sorting, cells expressing high affinity antigen-specific antibodies are selected from a population of immune cells isolated from a mammal that has been immunized with or otherwise exposed to the antigen. Nucleic acids encoding the high affinity antibodies can then be cloned into other lymphoid and non-lymphoid cells where the antibody can be expressed and from which the antibodies can be secreted.
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公开(公告)号：EP3119811B1
公开(公告)日：2019-10-30
申请号：EP15715047.5
申请日：2015-03-20
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3.发明公开VL ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS 有权VL-ANGENBINDENDE蛋白质脱乙酰酶BINDUNGSEIGENSCHAFTEN
公开(公告)号：EP3119811A2
公开(公告)日：2017-01-25
申请号：EP15715047.5
申请日：2015-03-20
发明人： BABB, Robert , RAFIQUE, Ashique , HUANG, Tammy T. , SHI, Ergang , MACDONALD, Lynn , MURPHY, Andrew J.
摘要： Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
摘要翻译： 提供了与重链恒定区融合的用于制备，鉴定，分离和/或制备含有免疫球蛋白轻链可变结构域的结合蛋白的方法，包括体细胞超突变轻链可变结构域。 还提供了对小分子特异性的示例性结合蛋白。
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4.发明公开
公开(公告)号：EP4267608A1
公开(公告)日：2023-11-01
申请号：EP21847855.0
申请日：2021-12-22
发明人： CHEN, Gang , SHI, Ergang , LEE, Wen-Yi , SUH, David , FARR, Glen , BABB, Robert
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公开(公告)号：EP3870602A1
公开(公告)日：2021-09-01
申请号：EP19804919.9
申请日：2019-10-23
发明人： BABB, Robert , BOWERMAN, Natalie , CHEN, Gang , GURER, Cagan , HANSEN, Johanna , LEE, Wen-Yi , MEAGHER, Thomas , SUH, David
IPC分类号： C07K14/725
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公开(公告)号：EP2970437A1
公开(公告)日：2016-01-20
申请号：EP14722432.3
申请日：2014-03-13
发明人： BABB, Robert , MCWHIRTER, John , MACDONALD, Lynn , STEVENS, Sean , DAVIS, Samuel , BUCKLER, David R. , MEAGHER, Karolina A. , MURPHY, Andrew J. , LEVENKOVA, Natasha
IPC分类号： C07K16/00 , C07K16/46 , A01K67/027 , C12N15/85
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/515 , C07K2317/76 , C07K2317/92 , C12N15/8509
摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.
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公开(公告)号：EP4209507A1
公开(公告)日：2023-07-12
申请号：EP22210926.6
申请日：2020-07-20
发明人： BABB, Robert , BAUM, Alina , CHEN, Gang , GERSON, Cindy , HANSEN, Johanna , HUANG, Tammy , KYRATSOUS, Christos , LEE, Wen-Yi , MALBEC, Marine , MURPHY, Andrew , OLSON, William , STAHL, Neil , YANCOPOULOS, George D.
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).
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公开(公告)号：EP3889177A1
公开(公告)日：2021-10-06
申请号：EP20186667.0
申请日：2020-07-20
发明人： BABB, Robert , BAUM, Alina , CHEN, Gang , GERSON, Cindy , HANSEN, Johanna , HUANG, Tammy , KYRATSOUS, Christos , LEE, Wen-Yi , MALBEC, Marine , MURPHY, Andrew , OLSON, William , STAHL, Neil , YANCOPOULOS, George D.
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections ( e.g ., coronavirus infections).
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公开(公告)号：EP3353212A1
公开(公告)日：2018-08-01
申请号：EP16781236.1
申请日：2016-09-23
发明人： SMITH, Eric , HABER, Lauric , BABB, Robert , CHEN, Gang , MACDONALD, Douglas
CPC分类号： C07K16/2809 , A61K2039/505 , A61P35/00 , C07K16/2863 , C07K16/3069 , C07K16/40 , C07K16/468 , C07K2317/31 , C07K2317/55 , C07K2317/92
摘要： The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain embodiments, the antibodies of the invention bind human CD3 with low affinity and induce human T cell proliferation and hence induce T cell-mediated killing of tumor cells with high efficacy. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3 with weak or no detectable binding affinity in an in vitro assay, and a second antigen-binding molecule that specifically binds human tumor-associated antigen. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing target antigen, such as PSMA. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced targeted immune response is desired and/or therapeutically beneficial. For example, the antibodies of the invention are useful for the treatment of various cancers or other diseases where immunotherapy, i.e. effector cell immunomodulation is warranted.
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10.发明公开NON-HUMAN ANIMALS THAT SELECT FOR LIGHT CHAIN VARIABLE REGIONS THAT BIND ANTIGEN 审中-公开选择与抗原结合的轻链可变区的非人动物
公开(公告)号：EP3271403A1
公开(公告)日：2018-01-24
申请号：EP16716981.2
申请日：2016-03-18
发明人： MACDONALD, Lynn , MURPHY, Andrew J. , GURER, Cagan , BABB, Robert
IPC分类号： C07K16/46 , A01K67/027 , C07K16/00 , C07K16/28
CPC分类号： C07K16/468 , A01K67/0278 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/92
摘要： Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise an immunoglobulin heavy chain locus that includes unrearranged human immunoglobulin light chain gene segments and an immunoglobulin light chain locus that includes a single rearranged human light chain variable region nucleotide sequence. The unrearranged human light chain gene segments may be operably linked to a heavy chain constant region nucleotide sequence and the rearranged human immunoglobulin light chain variable region nucleotide sequence may be operably linked to a light chain constant region nucleotide sequence. Also provided are methods for obtaining nucleic acid sequences that encode immunoglobulin light chain variable domains capable of binding an antigen in the absence of a cognate variable domain, and expressing such nucleic acid sequences in a host cell, e.g., to generate a multispecific antigen-binding protein.
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