发明公开
- 专利标题: BINDING MOLECULES FOR BCMA AND CD3
- 专利标题(中): BINDEMOLEKÜLEFÜRBCMA UND CD3
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申请号: EP14716251.5申请日: 2014-03-14
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公开(公告)号: EP2970472A1公开(公告)日: 2016-01-20
- 发明人: KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
- 申请人: Amgen Research (Munich) GmbH , Boehringer Ingelheim International GmbH
- 申请人地址: Staffelseestrasse 2 81477 München DE
- 专利权人: Amgen Research (Munich) GmbH,Boehringer Ingelheim International GmbH
- 当前专利权人: Amgen Research (Munich) GmbH,Boehringer Ingelheim International GmbH
- 当前专利权人地址: Staffelseestrasse 2 81477 München DE
- 代理机构: Schiweck, Weinzierl & Koch
- 优先权: US201361793235P 20130315
- 国际公布: WO2014140248 20140918
- 主分类号: C07K16/28
- IPC分类号: C07K16/28
摘要:
The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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