发明公开
EP2976343A2 SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
审中-公开
N-BIPHENYL-3-乙酰氨基苯甲酰胺在N- [3-（乙酰氨基）苯基] - 联苯甲酰胺在DEREN VERWENDUNG ALS INHIBITOREN DES WNT-SIGNALTRANSDUKESWEGES
- 专利标题： SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
- 专利标题（中）： N-BIPHENYL-3-乙酰氨基苯甲酰胺在N- [3-（乙酰氨基）苯基] - 联苯甲酰胺在DEREN VERWENDUNG ALS INHIBITOREN DES WNT-SIGNALTRANSDUKESWEGES
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申请号： EP14711513.3申请日： 2014-03-20
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公开(公告)号： EP2976343A2公开(公告)日： 2016-01-27
- 发明人: THEDE, Kai , SCOTT, William Johnston , BENDER, Eckhard , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , RICHTER, Anja , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , ZORN, Ludwig
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： US201361803552P 20130320
- 国际公布： WO2014147182 20140925
- 主分类号： C07D491/08
- IPC分类号： C07D491/08 ; C07C271/24 ; C07D231/12 ; C07C317/48 ; C07C317/50 ; C07D413/12 ; C07C323/63 ; C07C233/54 ; C07C233/80 ; C07D205/04 ; C07D265/30 ; C07D491/10 ; A61K31/4418 ; A61P35/00 ; C07C237/40
摘要：
The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.
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