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公开(公告)号：EP3306692B1
公开(公告)日：2020-03-11
申请号：EP16800030.5
申请日：2016-05-25
发明人： ENDO, Toshiyuki , NAKAZAWA, Taichi
IPC分类号： H01L51/54 , C07C231/12 , C07C233/80 , C09K11/06 , C07B61/00
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公开(公告)号：EP3309851A4
公开(公告)日：2018-06-06
申请号：EP16811553
申请日：2016-06-10
发明人： NAKAZAWA TAICHI , ENDO TOSHIYUKI , TAKAYAMA YUKI
IPC分类号： C07C233/75 , C07C233/80 , C07D209/88 , C09D5/24 , H01L51/50
CPC分类号： C07C233/75 , C07C233/80 , C07C2603/18 , C07D209/88 , C09D5/24 , H01L51/50
摘要： Provided is a charge-transporting varnish which comprises an amide compound containing fluorine atoms and represented by formula (1) and a charge-transporting substance. [In the formula, Ar 1 represents a group represented by any of formulae (1-1) to (1-9) and Ar 2 and Ar 3 each represent a given fluorinated aryl or aralkyl group.]
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3.发明公开WATER-DISPERSIBLE AMORPHOUS PARTICLES AND METHOD FOR PREPARING SAME 审中-公开VERFAHREN ZUR HERSTELLUNG DAVON的WASSERDISPERGIERBARE AMORPHE PARTIKEL
公开(公告)号：EP3118276A1
公开(公告)日：2017-01-18
申请号：EP15760926.4
申请日：2015-03-09
发明人： NAKAMURA, Eiichi , HARANO, Koji , INAKOSHI, Naoto , LIU, Chao
IPC分类号： C09K3/00 , A61K9/14 , B01D9/02 , B01J2/10 , B01J13/00 , B82Y5/00 , C07C13/62 , C07C15/20 , C07C15/38 , C07C22/08 , C07C63/44 , C07C69/616 , C07C233/80 , C07D235/20 , C07D309/10 , C07D401/12 , C07F7/18 , C07F9/53 , C07J9/00
CPC分类号： A61K9/5192 , A61K9/14 , A61K9/51 , A61K31/167 , A61K31/366 , A61K31/4184 , A61K31/4439 , A61K31/575 , C07F7/0818 , C07F9/5325
摘要： The present invention pertains to spherical water-dispersible amorphous particles having a particle diameter of 10-990 nm and a PDI of 0.01-0.5, wherein the amorphous particles contain an organic compound having a molecular weight of 50-1500, and a method for preparing the same.
摘要翻译： 本发明涉及粒径为10-990nm，PDI为0.01-0.5的球形水分散无定形颗粒，其中无定形颗粒含有分子量为50-1500的有机化合物，以及制备方法 一样。
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4.发明公开PHENYL DIAMIDES AND A PHARMACEUTICAL PREPARATION COMPRISING PHENYL DIAMIDES 审中-公开苯基二酰胺和包含苯基二酰胺的药物制剂
公开(公告)号：EP2625168A1
公开(公告)日：2013-08-14
申请号：EP11764198.5
申请日：2011-10-04
发明人： FAMULOK, Michael , BILL, Anke , SCHMITZ, Anton , BAJORATH, Jürgen
IPC分类号： C07D213/81 , C07D307/68 , C07C233/80 , C07D307/54 , C07D317/60 , C07D319/18 , A61K31/4409 , A61K31/341 , A61K31/357 , A61P35/00
CPC分类号： A61K31/167 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/4409 , C07C233/80 , C07D213/81 , C07D307/54 , C07D307/68 , C07D317/60 , C07D319/18
摘要： The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1). Further, the present invention relates to phenyl diamides according to the formulas (16), (17) and (18) for use in the treatment of gliomas.
摘要翻译： 本发明涉及根据通式（1）的苯基二酰胺及其作为药物和包含根据通式（1）的苯基二酰胺作为活性成分的药物制剂的用途。 此外，本发明涉及用于治疗神经胶质瘤的根据式（16），（17）和（18）的苯基二酰胺。
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公开(公告)号：EP1474408B1
公开(公告)日：2012-05-23
申请号：EP03737319.8
申请日：2003-02-06
申请人： Novartis AG , Novartis Pharma GmbH
发明人： LOISELEUR, Olivier , KAUFMANN, Daniel , ABEL, Stephan , BUERGER, Hans, Michael , MEISENBACH, Mark , SCHMITZ, Beat , SEDELMEIER, Gottfried
IPC分类号： C07D295/12 , C07C237/40 , C07D401/04 , C07C233/80
CPC分类号： C07D401/04 , C07D295/155 , C07D401/14
摘要： The present invention relates to novel amides and a process for preparing these amides.
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6.发明授权SUBSTITUTED (4-AMINOCYCLOHEXEN-1-YL)PHENYL AND (4-AMINOCYCLOHEXEN-1-YL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS 有权取代基（4-氨基环戊烯-1-基）苯基和（4-氨基环己烷-1-基）吡啶基缬氨二醛5-HT1F AGONISTEN
公开(公告)号：EP1697305B1
公开(公告)日：2007-08-15
申请号：EP04816953.6
申请日：2004-12-06
IPC分类号： C07C233/80 , C07D213/75 , A61K31/165 , A61K31/44 , A61P25/06
CPC分类号： C07D213/73 , C07C233/80 , C07C2601/16 , C07C2601/18 , C07D213/61 , C07D213/75
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is -C(R4)= or -N=; Ar is phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R1 and R2 are independantly hydrogen or C1-C3 alkyl; R3 is hydrogen, fluoro, or methyl; when X is -C(R4)=, R4 is hydrogen, fluoro, or methyl, provided that no more than one of R3 and R4 may be other than hydrogen; and R5 is hydrogen, methyl, or ethyl. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting dural protein extravasation, and for the treatment or prevention of migraine in a mammal.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的酸加成盐，其中： X是-C（R 4） - 或-N-; Ar是苯基，取代的苯基，杂环或取代的杂环; R 1和R 2独立地是氢或C 1 -C 3烷基; R 3是氢，氟或甲基; 当X是-C（R 4） - ）时，R 4是氢，氟或甲基，条件是R 3不超过一个 >和R 4可以不同于氢; R 5是氢，甲基或乙基。 本发明的化合物可用于活化5-HT 1F受体，抑制硬脑膜蛋白质外渗，以及治疗或预防哺乳动物偏头痛。
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公开(公告)号：EP1014962A4
公开(公告)日：2007-06-27
申请号：EP98932928
申请日：1998-06-26
申请人： LILLY CO ELI
发明人： BEIGHT DOUGLAS WADE , CRAFT TRELIA JOYCE , FRANCISKOVICH JEFFRY BERNARD , GOODSON THEODORE JR , HALL STEVEN EDWARD , HERRON DAVID KENT , KLIMKOWSKI VALENTINE JOSEPH , KYLE JEFFREY ALAN , MASTERS JOHN JOSEPH , MENDEL DAVID , MILOT GUY , SAWYER JASON SCOTT , SHUMAN ROBERT THEODORE , SMITH GERALD FLOYD , TEBBE ANNE LOUISE , TINSLEY JENNIFER MARIE , WEIR LEONARD CRAYTON , WIKEL JAMES HOWARD , WILEY MICHAEL ROBERT
IPC分类号： C07D295/18 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/235 , A61K31/27 , A61K31/36 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/4525 , A61K31/4535 , A61K31/4545 , A61K31/5375 , A61P7/02 , C07C233/75 , C07C233/80 , C07C235/42 , C07C235/56 , C07C235/84 , C07C237/40 , C07C237/42 , C07C237/44 , C07C257/18 , C07C259/18 , C07C307/10 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/21 , C07C317/44 , C07C317/50 , C07C323/62 , C07D209/48 , C07D209/58 , C07D209/64 , C07D209/66 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/62 , C07D211/78 , C07D211/96 , C07D213/30 , C07D213/56 , C07D213/70 , C07D213/74 , C07D213/75 , C07D233/60 , C07D261/10 , C07D277/20 , C07D277/38 , C07D277/56 , C07D295/185 , C07D307/84 , C07D307/85 , C07D317/58 , C07D317/66 , C07D333/68 , C07D333/70 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/06 , A61K31/165 , A61K31/335 , A61K31/34 , A61K31/38 , A61K31/40
CPC分类号： C07D209/48 , C07C233/75 , C07C235/56 , C07C237/40 , C07C237/42 , C07C237/44 , C07C257/18 , C07C259/18 , C07C307/10 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/21 , C07C317/44 , C07C317/50 , C07C2603/18 , C07D209/58 , C07D209/64 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/62 , C07D211/78 , C07D211/96 , C07D213/30 , C07D213/56 , C07D213/70 , C07D213/75 , C07D261/10 , C07D277/56 , C07D295/185 , C07D307/85 , C07D317/58 , C07D333/70 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/06
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8.发明授权BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS 有权BIPHENYLCARBONSÄUREAMIDE，DIE SICH ALS LIPIDSENKER EIGNEN
公开(公告)号：EP1339685B1
公开(公告)日：2006-11-02
申请号：EP01997477.3
申请日：2001-11-15
IPC分类号： C07D211/58 , C07D207/14 , C07C233/80 , A61K31/40 , A61K31/402 , A61K31/445 , A61K31/216 , A61P3/06 , A61P3/10
CPC分类号： C07C237/20 , C07C233/80 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D211/58
摘要： Biphenylcarboxamide compounds of formula (I), methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
摘要翻译： 用于制备这种化合物的式（I）的联苯甲酰胺化合物，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。
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9.发明公开SUBSTITUTED (4-AMINOCYCLOHEXEN-1-YL)PHENYL AND (4-AMINOCYCLOHEXEN-1-YL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS 有权取代的（4- AMINOCYCLOHEXEN -1-基）苯基和（4- AMINOCYCLOHEXEN -1-基）吡啶基化合物作为5-HT1F激动剂
公开(公告)号：EP1697305A1
公开(公告)日：2006-09-06
申请号：EP04816953.6
申请日：2004-12-06
IPC分类号： C07C233/80 , C07D213/75 , A61K31/165 , A61K31/44 , A61P25/06
CPC分类号： C07D213/73 , C07C233/80 , C07C2601/16 , C07C2601/18 , C07D213/61 , C07D213/75
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is -C(R4)= or -N=; Ar is phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R1 and R2 are independantly hydrogen or C1-C3 alkyl; R3 is hydrogen, fluoro, or methyl; when X is -C(R4)=, R4 is hydrogen, fluoro, or methyl, provided that no more than one of R3 and R4 may be other than hydrogen; and R5 is hydrogen, methyl, or ethyl. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting dural protein extravasation, and for the treatment or prevention of migraine in a mammal.
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10.发明公开
公开(公告)号：EP1517881A1
公开(公告)日：2005-03-30
申请号：EP03761545.7
申请日：2003-06-27
发明人： ZAMBACH, Werner,Syngenta Crop Protection AG , RENOLD, Peter,Syngenta Crop Protection AG , STEIGER, Arthur,Syngenta Crop Protection AG , TRAH, Stephan,Syngenta Crop Protection AG , HALL, Roger Graham,Syngenta Crop Protection AG
IPC分类号： C07C233/75 , C07C233/60 , C07C233/25 , C07C233/61 , C07C233/33 , C07C233/76 , C07C233/80 , C07C233/62 , C07C233/34 , C07C271/58 , C07C271/28 , C07C217/84 , A01N47/20 , A01N39/00 , A01N37/24 , A01N33/02
CPC分类号： C07D207/27 , C07C217/84 , C07C233/25 , C07C233/29 , C07C233/75 , C07C271/28 , C07D207/325 , C07D207/444 , C07D207/452 , C07D263/22 , C07D307/68 , C07D333/38
摘要： Compounds of formula (I), wherein A1, A2 and A3 are each independently of the others a bond or a C1-C6alkylene bridge; A4 is a C1-C6alkylene bridge; Di s CH or N; W is, for example, O, NR7 or S; T is, for example, a bond, O, NH or NR7; Q is O, NR7, S, SO or SO2; Y is O, NR7, S, SO, or SO2; X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 ar, for example, H, halogen, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl or C2-C6alkenyl; R4 is, for example, H, halogen, CN, nitro or C1-C6alkyl; R5 and R6 are, for example, H, CN, OH, C1-C6alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C6alkyl, C1-C6 haloalky, C1-C6alkoxy or C1-C6haloalkoxy; R7 is H, C1-C6alkyl, C1-C6alkoxyalkyl or C1-C6alkylcarbonyl; k, when D is nitrogen, is 1, 2 or 3; or, when D is CH, is 1, 2, 3 or 4; and m is 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds or an agrochemically acceptable salt thereof, a process for the preparation of those compositions and their use, plant propagation material treated with those compositions, and a method of controlling pests.
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