发明公开
EP2988749A1 THIAZOLE-SUBSTITUTED AMINOPYRIMIDINES AS SPLEEN TYROSINE KINASE INHIBITORS
有权
噻唑取代的氨基嘧啶作为SPLEEN酪氨酸激酶抑制剂
- 专利标题： THIAZOLE-SUBSTITUTED AMINOPYRIMIDINES AS SPLEEN TYROSINE KINASE INHIBITORS
- 专利标题（中）： 噻唑取代的氨基嘧啶作为SPLEEN酪氨酸激酶抑制剂
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申请号： EP14788786.3申请日： 2014-04-22
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公开(公告)号： EP2988749A1公开(公告)日： 2016-03-02
- 发明人: ARRINGTON, Kenneth, L. , DUBOIS, Byron , DEBENHAM, John, S. , LIU, Ping , NORTHRUP, Alan, B. , SZEWCZYK, Jason, W. , WANG, Liping , WANG, Ming
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Hussain, Deeba
- 优先权： US201361816411P 20130426
- 国际公布： WO2014176216 20141030
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61P29/00 ; C07D417/14
摘要：
The invention provides certain thiazole-substituted aminopyrimidine compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, and the subscripts r, s, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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